Glycosylation of an allenic erythronolide

Libing Yu, Huan Wang, Novruz Akhmedov, Lawrence J. Williams

Research output: Contribution to journalArticlepeer-review

Abstract

A concise route to a glycosylated allenic erythronolide was achieved. Key findings include the preparation of a desosamine sulfoxide donor and the use of the donor to glycosylate bulky acceptors. Additionally, the new reagent was used to prepare allene-containing macrocycles and to realize a four-step synthesis of macrolide 6 from bis[allene] 5. The longest linear sequence required to prepare 6 from commercial reagents was 15 steps.

Original languageEnglish (US)
Pages (from-to)432-436
Number of pages5
JournalJournal of Antibiotics
Volume72
Issue number6
DOIs
StatePublished - Jun 1 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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