Glycosylation regulates Notch signalling

Nicola Haines, Kenneth D. Irvine

Research output: Contribution to journalReview articlepeer-review

320 Scopus citations


Intracellular post-translational modifications such as phosphorylation and ubiquitylation have been well studied for their roles in regulating diverse signalling pathways, but we are only just beginning to understand how differential glycosylation is used to regulate intercellular signalling. Recent studies make clear that extracellular post-translational modifications, in the form of glycosylation, are essential for the Notch signalling pathway, and that differences in the extent of glycosylation are a significant mechanism by which this pathway is regulated.

Original languageEnglish (US)
Pages (from-to)786-797
Number of pages12
JournalNature Reviews Molecular Cell Biology
Issue number10
StatePublished - Oct 1 2003

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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