Growth cone collapse assay

Xin Yue, Alexander I. Son, Renping Zhou

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Growth cone collapse is an easy and efficient test for detecting and characterizing axon guidance activities secreted or expressed by cells. It can also be used to dissect signaling pathways by axon growth inhibitors and to isolate therapeutic compounds that promote axon regeneration. Here, we describe a growth cone collapse assay protocol used to study signal transduction mechanisms of the repulsive axon guidance molecule ephrin-A5 in hippocampal neurons.

Original languageEnglish (US)
Title of host publicationNeural Development
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Number of pages7
ISBN (Print)9781627034432
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics


  • Ephrins
  • F-actin
  • Filopodia
  • Hippocampus
  • Lamellipodia
  • Neurons


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