Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

Liping Zhao; Feng Zhang; Xiaoying Ding; Guojun Wu; Yan Y. Lam; Xuejiao Wang; Huaqing Fu; Xinhe Xue; Chunhua Lu; Jilin Ma; Lihua Yu; Chengmei Xu; Zhongying Ren; Ying Xu; Songmei Xu; Hongli Shen; Xiuli Zhu; Yu Shi; Qingyun Shen; Weiping Dong; Rui Liu; Yunxia Ling; Yue Zeng; Xingpeng Wang; Qianpeng Zhang; Jing Wang; Linghua Wang; Yanqiu Wu; Benhua Zeng; Hong Wei; Menghui Zhang; Yongde Peng; Chenhong Zhang

doi:10.1126/science.aao5774

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

Liping Zhao, Feng Zhang, Xiaoying Ding, Guojun Wu, Yan Y. Lam, Xuejiao Wang, Huaqing Fu, Xinhe Xue, Chunhua Lu, Jilin Ma, Lihua Yu, Chengmei Xu, Zhongying Ren, Ying Xu, Songmei Xu, Hongli Shen, Xiuli Zhu, Yu Shi, Qingyun Shen, Weiping DongRui Liu, Yunxia Ling, Yue Zeng, Xingpeng Wang, Qianpeng Zhang, Jing Wang, Linghua Wang, Yanqiu Wu, Benhua Zeng, Hong Wei, Menghui Zhang, Yongde Peng, Chenhong Zhang

School of Environmental and Biological Sciences, Biochemistry & Microbiology

Research output: Contribution to journal › Article › peer-review

1595 Scopus citations

Abstract

The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.

Original language	English (US)
Pages (from-to)	1151-1156
Number of pages	6
Journal	Science
Volume	359
Issue number	6380
DOIs	https://doi.org/10.1126/science.aao5774
State	Published - Mar 9 2018

All Science Journal Classification (ASJC) codes

General

Access to Document

10.1126/science.aao5774

Cite this

@article{de6ddce553c44e3cb48b607aff3a1c32,

title = "Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes",

abstract = "The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.",

author = "Liping Zhao and Feng Zhang and Xiaoying Ding and Guojun Wu and Lam, {Yan Y.} and Xuejiao Wang and Huaqing Fu and Xinhe Xue and Chunhua Lu and Jilin Ma and Lihua Yu and Chengmei Xu and Zhongying Ren and Ying Xu and Songmei Xu and Hongli Shen and Xiuli Zhu and Yu Shi and Qingyun Shen and Weiping Dong and Rui Liu and Yunxia Ling and Yue Zeng and Xingpeng Wang and Qianpeng Zhang and Jing Wang and Linghua Wang and Yanqiu Wu and Benhua Zeng and Hong Wei and Menghui Zhang and Yongde Peng and Chenhong Zhang",

note = "Publisher Copyright: 2017 {\textcopyright} The Authors.",

year = "2018",

month = mar,

day = "9",

doi = "10.1126/science.aao5774",

language = "English (US)",

volume = "359",

pages = "1151--1156",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6380",

}

Zhao, L, Zhang, F, Ding, X, Wu, G, Lam, YY, Wang, X, Fu, H, Xue, X, Lu, C, Ma, J, Yu, L, Xu, C, Ren, Z, Xu, Y, Xu, S, Shen, H, Zhu, X, Shi, Y, Shen, Q, Dong, W, Liu, R, Ling, Y, Zeng, Y, Wang, X, Zhang, Q, Wang, J, Wang, L, Wu, Y, Zeng, B, Wei, H, Zhang, M, Peng, Y & Zhang, C 2018, 'Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes', Science, vol. 359, no. 6380, pp. 1151-1156. https://doi.org/10.1126/science.aao5774

TY - JOUR

T1 - Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

AU - Zhao, Liping

AU - Zhang, Feng

AU - Ding, Xiaoying

AU - Wu, Guojun

AU - Lam, Yan Y.

AU - Wang, Xuejiao

AU - Fu, Huaqing

AU - Xue, Xinhe

AU - Lu, Chunhua

AU - Ma, Jilin

AU - Yu, Lihua

AU - Xu, Chengmei

AU - Ren, Zhongying

AU - Xu, Ying

AU - Xu, Songmei

AU - Shen, Hongli

AU - Zhu, Xiuli

AU - Shi, Yu

AU - Shen, Qingyun

AU - Dong, Weiping

AU - Liu, Rui

AU - Ling, Yunxia

AU - Zeng, Yue

AU - Wang, Xingpeng

AU - Zhang, Qianpeng

AU - Wang, Jing

AU - Wang, Linghua

AU - Wu, Yanqiu

AU - Zeng, Benhua

AU - Wei, Hong

AU - Zhang, Menghui

AU - Peng, Yongde

AU - Zhang, Chenhong

PY - 2018/3/9

Y1 - 2018/3/9

N2 - The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.

AB - The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.

UR - http://www.scopus.com/inward/record.url?scp=85043228831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043228831&partnerID=8YFLogxK

U2 - 10.1126/science.aao5774

DO - 10.1126/science.aao5774

M3 - Article

C2 - 29590046

AN - SCOPUS:85043228831

SN - 0036-8075

VL - 359

SP - 1151

EP - 1156

JO - Science

JF - Science

IS - 6380

ER -

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this