H-phosphonate DNA synthesis without amino protection

Pei Pei Kung; Roger A. Jones

doi:10.1016/S0040-4039(00)61075-4

H-phosphonate DNA synthesis without amino protection

Pei Pei Kung, Roger A. Jones

School of Arts and Sciences, Chemistry & Chemical Biology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

DNA synthesis by H-phosphonate method does not require the use of amino protecting groups. The cytosine amino group, and the guanine 06/N1 positions, do react with the condensing agent to some extent, but these derivatives are cleaved under the standard aqueous ammonia conditions commonly used for deproctection and cleavage of the oligonucleotide from the solid support.

Original language	English (US)
Pages (from-to)	5869-5872
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	40
DOIs	https://doi.org/10.1016/S0040-4039(00)61075-4
State	Published - Sep 29 1992

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

H-phosphonate
Oligonucleotide synthesis

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10.1016/S0040-4039(00)61075-4

Cite this

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title = "H-phosphonate DNA synthesis without amino protection",

abstract = "DNA synthesis by H-phosphonate method does not require the use of amino protecting groups. The cytosine amino group, and the guanine 06/N1 positions, do react with the condensing agent to some extent, but these derivatives are cleaved under the standard aqueous ammonia conditions commonly used for deproctection and cleavage of the oligonucleotide from the solid support.",

keywords = "H-phosphonate, Oligonucleotide synthesis",

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doi = "10.1016/S0040-4039(00)61075-4",

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T1 - H-phosphonate DNA synthesis without amino protection

AU - Kung, Pei Pei

AU - Jones, Roger A.

PY - 1992/9/29

Y1 - 1992/9/29

N2 - DNA synthesis by H-phosphonate method does not require the use of amino protecting groups. The cytosine amino group, and the guanine 06/N1 positions, do react with the condensing agent to some extent, but these derivatives are cleaved under the standard aqueous ammonia conditions commonly used for deproctection and cleavage of the oligonucleotide from the solid support.

AB - DNA synthesis by H-phosphonate method does not require the use of amino protecting groups. The cytosine amino group, and the guanine 06/N1 positions, do react with the condensing agent to some extent, but these derivatives are cleaved under the standard aqueous ammonia conditions commonly used for deproctection and cleavage of the oligonucleotide from the solid support.

KW - H-phosphonate

KW - Oligonucleotide synthesis

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U2 - 10.1016/S0040-4039(00)61075-4

DO - 10.1016/S0040-4039(00)61075-4

M3 - Article

AN - SCOPUS:0026475476

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VL - 33

SP - 5869

EP - 5872

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 40

ER -

H-phosphonate DNA synthesis without amino protection

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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