Habitat-Specific Clock Variation and Its Consequence on Reproductive Fitness

Bala S.C. Koritala, Craig Wager, Joshua C. Waters, Ryan Pachucki, Benedetto Piccoli, Yaping Feng, Laura B. Scheinfeldt, Sunil M. Shende, Sohyun Park, James I. Hozier, Parth Lalakia, Dibyendu Kumar, Kwangwon Lee

Research output: Contribution to journalArticle

Abstract

The circadian clock controls daily activities at the cellular and organismic level, allowing an organism to anticipate incoming stresses and to use resources accordingly. The circadian clock has therefore been considered a fitness trait in multiple organisms. However, the mechanism of how circadian clock variation influences organismal reproductive fitness is still not well understood. Here we describe habitat-specific clock variation (HSCV) of asexual reproduction in Neurospora discreta, a species that is adapted to 2 different habitats, under or above tree bark. African (AF) N. discreta strains, whose habitat is above the tree bark in light-dark (LD) conditions, display a higher rhythmicity index compared with North American (NA) strains, whose habitat is under the tree bark in constant dark (DD). Although AF-type strains demonstrated an overall fitness advantage under LD and DD conditions, NA-type strains exhibit a habitat-specific fitness advantage in DD over the LD condition. In addition, we show that allelic variation of the clock-controlled gene, Ubiquinol cytochrome c oxidoreductase (NEUDI_158280), plays a role in HSCV by modulating cellular reactive oxygen species levels. Our results demonstrate a mechanism by which local adaptation involving circadian clock regulation influences reproductive fitness.

Original languageEnglish (US)
Pages (from-to)134-144
Number of pages11
JournalJournal of Biological Rhythms
Volume35
Issue number2
DOIs
StatePublished - Apr 1 2020

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Keywords

  • adaptation
  • circadian clock
  • fitness
  • habitat
  • natural variation

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    Koritala, B. S. C., Wager, C., Waters, J. C., Pachucki, R., Piccoli, B., Feng, Y., Scheinfeldt, L. B., Shende, S. M., Park, S., Hozier, J. I., Lalakia, P., Kumar, D., & Lee, K. (2020). Habitat-Specific Clock Variation and Its Consequence on Reproductive Fitness. Journal of Biological Rhythms, 35(2), 134-144. https://doi.org/10.1177/0748730419896486