Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Cheavar A. Blair; Elizabeth A. Brundage; Katherine L. Thompson; Arnold Stromberg; Maya Guglin; Brandon J. Biesiadecki; Kenneth S. Campbell

doi:10.1016/j.jacbts.2020.05.014

Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Cheavar A. Blair, Elizabeth A. Brundage, Katherine L. Thompson, Arnold Stromberg, Maya Guglin, Brandon J. Biesiadecki, Kenneth S. Campbell

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca²⁺) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca²⁺ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.

Original language	English (US)
Pages (from-to)	786-798
Number of pages	13
Journal	JACC: Basic to Translational Science
Volume	5
Issue number	8
DOIs	https://doi.org/10.1016/j.jacbts.2020.05.014
State	Published - Aug 2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

Keywords

Ca sensitivity
heart failure
human myocardium
myofilament proteins
ventricular function

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10.1016/j.jacbts.2020.05.014

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title = "Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles",

abstract = "This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca2+) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca2+ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.",

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AU - Brundage, Elizabeth A.

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AU - Stromberg, Arnold

AU - Guglin, Maya

AU - Biesiadecki, Brandon J.

AU - Campbell, Kenneth S.

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AB - This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca2+) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca2+ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.

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Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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