Helicobacter pylori and gastrointestinal tract adenocarcinomas

Richard M. Peek, Martin J. Blaser

Research output: Contribution to journalReview articlepeer-review

1512 Scopus citations

Abstract

Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

Original languageEnglish (US)
Pages (from-to)28-37
Number of pages10
JournalNature Reviews Cancer
Volume2
Issue number1
DOIs
StatePublished - Jan 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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