Helicobacter pylori infection and the risk for duodenal and gastric ulceration

A. Nomura, G. N. Stemmermann, P. H. Chyou, G. I. Perez-Perez, Martin Blaser

Research output: Contribution to journalArticle

288 Citations (Scopus)

Abstract

Objective: To determine whether a preexisting Helicobacter pylori infection increases the risk for developing duodenal or gastric ulcer. Design: A nested case-control study based on a cohort of 5443 Japanese- American men who had a physical examination and a phlebotomy from 1967 to 1970. Setting: All 10 general hospitals on the Hawaiian island of Oahu. Patients: 150 patients with gastric ulcer and 65 patients with duodenal ulcer identified in the cohort of study participants after a hospital surveillance period of more than 20 years. Measurements: Stored serum specimens from patients and from matched controls were tested for the presence of serum IgG antibody to H. pylori using enzyme-linked immunosorbent assay. Results: 93% of the 150 patients with gastric ulcer and 78% of the matched controls had a positive antibody level for H. pylori-specific IgG, yielding an odds ratio of 3.2 (95% Cl, 1.6 to 6.5). For duodenal ulcer, 92% of the 65 patients and 78% of the matched controls had a positive test result, yielding an odds ratio of 4.0 (Cl, 1.1 to 14.2). As the level of antibody to H. pylori increased, a statistically significant increase was noted in the risk for gastric and duodenal ulcer. The association with H. pylori infection was statistically significant for both types of ulcer, even when the diagnosis was made 10 or more years after the serum sample had been obtained. Conclusion: Preexisting H. pylori infection increases the risk for subsequent development of either duodenal or gastric ulcer disease.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalAnnals of internal medicine
Volume120
Issue number12
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Helicobacter Infections
Helicobacter pylori
Stomach Ulcer
Duodenal Ulcer
Stomach
Antibodies
Immunoglobulin G
Serum
Odds Ratio
Stomach Diseases
Phlebotomy
Asian Americans
Islands
General Hospitals
Physical Examination
Ulcer
Case-Control Studies
Cohort Studies
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Nomura, A. ; Stemmermann, G. N. ; Chyou, P. H. ; Perez-Perez, G. I. ; Blaser, Martin. / Helicobacter pylori infection and the risk for duodenal and gastric ulceration. In: Annals of internal medicine. 1994 ; Vol. 120, No. 12. pp. 977-981.
@article{870556ac32254499becff08946691649,
title = "Helicobacter pylori infection and the risk for duodenal and gastric ulceration",
abstract = "Objective: To determine whether a preexisting Helicobacter pylori infection increases the risk for developing duodenal or gastric ulcer. Design: A nested case-control study based on a cohort of 5443 Japanese- American men who had a physical examination and a phlebotomy from 1967 to 1970. Setting: All 10 general hospitals on the Hawaiian island of Oahu. Patients: 150 patients with gastric ulcer and 65 patients with duodenal ulcer identified in the cohort of study participants after a hospital surveillance period of more than 20 years. Measurements: Stored serum specimens from patients and from matched controls were tested for the presence of serum IgG antibody to H. pylori using enzyme-linked immunosorbent assay. Results: 93{\%} of the 150 patients with gastric ulcer and 78{\%} of the matched controls had a positive antibody level for H. pylori-specific IgG, yielding an odds ratio of 3.2 (95{\%} Cl, 1.6 to 6.5). For duodenal ulcer, 92{\%} of the 65 patients and 78{\%} of the matched controls had a positive test result, yielding an odds ratio of 4.0 (Cl, 1.1 to 14.2). As the level of antibody to H. pylori increased, a statistically significant increase was noted in the risk for gastric and duodenal ulcer. The association with H. pylori infection was statistically significant for both types of ulcer, even when the diagnosis was made 10 or more years after the serum sample had been obtained. Conclusion: Preexisting H. pylori infection increases the risk for subsequent development of either duodenal or gastric ulcer disease.",
author = "A. Nomura and Stemmermann, {G. N.} and Chyou, {P. H.} and Perez-Perez, {G. I.} and Martin Blaser",
year = "1994",
month = "1",
day = "1",
doi = "10.7326/0003-4819-120-12-199406150-00001",
language = "English (US)",
volume = "120",
pages = "977--981",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "12",

}

Helicobacter pylori infection and the risk for duodenal and gastric ulceration. / Nomura, A.; Stemmermann, G. N.; Chyou, P. H.; Perez-Perez, G. I.; Blaser, Martin.

In: Annals of internal medicine, Vol. 120, No. 12, 01.01.1994, p. 977-981.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Helicobacter pylori infection and the risk for duodenal and gastric ulceration

AU - Nomura, A.

AU - Stemmermann, G. N.

AU - Chyou, P. H.

AU - Perez-Perez, G. I.

AU - Blaser, Martin

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Objective: To determine whether a preexisting Helicobacter pylori infection increases the risk for developing duodenal or gastric ulcer. Design: A nested case-control study based on a cohort of 5443 Japanese- American men who had a physical examination and a phlebotomy from 1967 to 1970. Setting: All 10 general hospitals on the Hawaiian island of Oahu. Patients: 150 patients with gastric ulcer and 65 patients with duodenal ulcer identified in the cohort of study participants after a hospital surveillance period of more than 20 years. Measurements: Stored serum specimens from patients and from matched controls were tested for the presence of serum IgG antibody to H. pylori using enzyme-linked immunosorbent assay. Results: 93% of the 150 patients with gastric ulcer and 78% of the matched controls had a positive antibody level for H. pylori-specific IgG, yielding an odds ratio of 3.2 (95% Cl, 1.6 to 6.5). For duodenal ulcer, 92% of the 65 patients and 78% of the matched controls had a positive test result, yielding an odds ratio of 4.0 (Cl, 1.1 to 14.2). As the level of antibody to H. pylori increased, a statistically significant increase was noted in the risk for gastric and duodenal ulcer. The association with H. pylori infection was statistically significant for both types of ulcer, even when the diagnosis was made 10 or more years after the serum sample had been obtained. Conclusion: Preexisting H. pylori infection increases the risk for subsequent development of either duodenal or gastric ulcer disease.

AB - Objective: To determine whether a preexisting Helicobacter pylori infection increases the risk for developing duodenal or gastric ulcer. Design: A nested case-control study based on a cohort of 5443 Japanese- American men who had a physical examination and a phlebotomy from 1967 to 1970. Setting: All 10 general hospitals on the Hawaiian island of Oahu. Patients: 150 patients with gastric ulcer and 65 patients with duodenal ulcer identified in the cohort of study participants after a hospital surveillance period of more than 20 years. Measurements: Stored serum specimens from patients and from matched controls were tested for the presence of serum IgG antibody to H. pylori using enzyme-linked immunosorbent assay. Results: 93% of the 150 patients with gastric ulcer and 78% of the matched controls had a positive antibody level for H. pylori-specific IgG, yielding an odds ratio of 3.2 (95% Cl, 1.6 to 6.5). For duodenal ulcer, 92% of the 65 patients and 78% of the matched controls had a positive test result, yielding an odds ratio of 4.0 (Cl, 1.1 to 14.2). As the level of antibody to H. pylori increased, a statistically significant increase was noted in the risk for gastric and duodenal ulcer. The association with H. pylori infection was statistically significant for both types of ulcer, even when the diagnosis was made 10 or more years after the serum sample had been obtained. Conclusion: Preexisting H. pylori infection increases the risk for subsequent development of either duodenal or gastric ulcer disease.

UR - http://www.scopus.com/inward/record.url?scp=0028292275&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028292275&partnerID=8YFLogxK

U2 - 10.7326/0003-4819-120-12-199406150-00001

DO - 10.7326/0003-4819-120-12-199406150-00001

M3 - Article

C2 - 7741826

AN - SCOPUS:0028292275

VL - 120

SP - 977

EP - 981

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 12

ER -