Helicobacter pylori persistence: Biology and disease

Martin J. Blaser, John C. Atherton

Research output: Contribution to journalReview articlepeer-review

738 Scopus citations

Abstract

Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the ecology of the indigenous microbiota. A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia.

Original languageEnglish (US)
Pages (from-to)321-333
Number of pages13
JournalJournal of Clinical Investigation
Volume113
Issue number3
DOIs
StatePublished - Feb 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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