Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor- α and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma

L. M. Minasian, T. P. Szatrowski, M. Rosenblum, T. Steffens, M. E. Morrison, P. B. Chapman, L. Williams, C. F. Nathan, A. N. Houghton

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Hemorrhagic tumor necrosis is an inflammatory event that leads to selective destruction of malignant tissues, with both potentially toxic and beneficial consequences. A pilot clinical trial was undertaken combining tumor necrosis factor-α (TNF-α) with the monoclonal antibody R24 (MoAb R24) against GD3 ganglioside in patients with metastatic melanoma. Patients received MoAb R24 to recruit leukocytes to the tumor followed by low doses of recombinant TNF-α to activate leukocytes. Eight patients were treated and seven patients had mild toxicity. One patient with extensive metastatic melanoma developed tumor lysis syndrome within hours after treatment with almost complete necrosis of bulky tumors in multiple visceral sites. To our knowledge, this is the first documented case of hemorrhagic tumor necrosis in a patient with metastatic cancer in multiple visceral sites.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalBlood
Volume83
Issue number1
DOIs
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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