Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats

Konglong Feng, Yaqi Lan, Xiaoai Zhu, Xiaoai Zhu, Jun Li, Tong Chen, Tong Chen, Qingrong Huang, Chi Tang Ho, Yunjiao Chen, Yong Cao

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Tangeretin (TAN) exhibited antilipogenic, antidiabetic, and lipid-lowering effects. However, the lipid biomarkers and the underlying mechanisms for antiobesity and cholesterol-lowering effects of TAN have not been sufficiently investigated. Herein, we integrated biochemical analysis with lipidomics to elucidate its efficacy and mechanisms in high-fat diet-fed rats. TAN at supplementation levels of 0.04 and 0.08% not only significantly decreased body weight gain, serum total cholesterol, and low-density lipoprotein cholesterol levels but also ameliorated hepatic steatosis. These beneficial effects were associated with the declining levels of fatty acids, diacylglycerols (DGs), triacylglycerols, ceramides, and cholesteryl esters by hepatic lipidomics analysis, which were attributed to downregulating lipogenesis-related genes and upregulating lipid oxidation- and bile acid biosynthesis-related genes. Additionally, 21 lipids were identified as potential lipid biomarkers, such as DGs and phosphatidylethanolamines. These findings indicated that the modulation of lipid homeostasis might be the key pathways for the mechanisms of TAN in the antiobesity and cholesterol-lowering effects.

Original languageEnglish (US)
Pages (from-to)6142-6153
Number of pages12
JournalJournal of agricultural and food chemistry
Volume68
Issue number22
DOIs
StatePublished - Jun 3 2020

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Keywords

  • antiobesity
  • cholesterol-lowering
  • diacyglycerols
  • lipidomics
  • tangeretin

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