Hepatitis C virus acute quadriparetic vasculitic neuropathy responsive to cyclophosphamide

Nizar Souayah, H. W. Sander, D. L. Menkes, S. L. Khella

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Purpose: Hepatitis C viral [HCV] infection is a chronic multisystem disorder that may have an indolent course initially. Peripheral neuropathy associated with cryoglobulinemia and a systemic vasculitis is a well-described complication of HCV infection. But this neuropathy is not known to have a late-onset acute fulminant phase. This acute fulminant phase is characterized by quadriparesis associated with pulmonary and/or renal insufficiency, and it may occur despite adequate treatment for HCV infection. The purpose of this study is to report that patients treated for chronic HCV infection may manifest a secondary progressive acute fulminant neuropathy associated with respiratory and/or renal insufficiency that is responsive to cyclophosphamide. Methods: Case series retrospective data analysis. Results: Three patients with biopsy-proven HCV associated vasculitic neuropathy manifested a secondary progressive acute fulminant course resulting in quadriparesis within 5 years of the initial diagnosis. Complete remission was achieved with cyclophosphamide therapy such that all patients became ambulatory. Conclusions: HCV-associated vasculitic neuropathy may manifest a secondary phase, which is acute, fulminant and progressive that is superimposed on an otherwise slowly progressive disorder. Cyclophosphamide therapy may abort progression and induce remission of this acute fulminant phase.

Original languageEnglish (US)
JournalNeurology, Neurophysiology and Neuroscience
StatePublished - 2006

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


  • Cryoglobulinemia
  • Cyclophosphamide
  • Hepatitis C
  • Peripheral neuropathy
  • Vasculitis


Dive into the research topics of 'Hepatitis C virus acute quadriparetic vasculitic neuropathy responsive to cyclophosphamide'. Together they form a unique fingerprint.

Cite this