Hepatocyte nuclear factor 3/fork head or 'winged helix' proteins: A family of transcription factors of diverse biologic function

E. Lai, K. L. Clark, S. K. Burley, J. E. Darnell

Research output: Contribution to journalReview articlepeer-review

302 Scopus citations

Abstract

A family of transcription factors, first identified as hepatocyte nuclear factors (HNF-3α, -3β, and -3γ) and as a homeotic Drosophila mutant, fork head, has been intensively studied for the past 4 years. Important findings have emerged about the structure of the DNA-binding portion of the proteins as well as biologic discoveries about the diversity of the family and its implied role in early development.

Original languageEnglish (US)
Pages (from-to)10421-10423
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number22
DOIs
StatePublished - 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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