Heritability and genomics of gene expression in peripheral blood

Fred A. Wright, Patrick F. Sullivan, Andrew I. Brooks, Fei Zou, Wei Sun, Kai Xia, Vered Madar, Rick Jansen, Wonil Chung, Yi Hui Zhou, Abdel Abdellaoui, Sandra Batista, Casey Butler, Guanhua Chen, Ting Huei Chen, David D'Ambrosio, Paul Gallins, Min Jin Ha, Jouke Jan Hottenga, Shunping HuangMathijs Kattenberg, Jaspreet Kochar, Christel M. Middeldorp, Ani Qu, Andrey Shabalin, Jay Tischfield, Laura Todd, Jung Ying Tzeng, Gerard Van Grootheest, Jacqueline M. Vink, Qi Wang, Wei Wang, Weibo Wang, Gonneke Willemsen, Johannes H. Smit, Eco J. De Geus, Zhaoyu Yin, Brenda W.J.H. Penninx, Dorret I. Boomsma

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly heritable genes (â ̂1/4777) were grouped into distinct expression clusters, enriched in gene-poor regions, associated with specific gene function or ontology classes, and strongly associated with disease designation. The design enabled a comparison of twin-based heritability to estimates based on dizygotic identity-by-descent sharing and distant genetic relatedness. Consideration of sampling variation suggests that previous heritability estimates have been upwardly biased. Genotyping of 2,494 twins enabled powerful identification of eQTLs, which we further examined in a replication set of 1,895 unrelated subjects. A large number of non-redundant local eQTLs (6,756) met replication criteria, whereas a relatively small number of distant eQTLs (165) met quality control and replication standards. Our results provide a new resource toward understanding the genetic control of transcription.

Original languageEnglish (US)
Pages (from-to)430-437
Number of pages8
JournalNature genetics
Volume46
Issue number5
DOIs
StatePublished - May 2014

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Quantitative Trait Loci
Genomics
Gene Expression
Genetic Transcription
Genes
Transcriptome
Quality Control

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Wright, F. A., Sullivan, P. F., Brooks, A. I., Zou, F., Sun, W., Xia, K., ... Boomsma, D. I. (2014). Heritability and genomics of gene expression in peripheral blood. Nature genetics, 46(5), 430-437. https://doi.org/10.1038/ng.2951
Wright, Fred A. ; Sullivan, Patrick F. ; Brooks, Andrew I. ; Zou, Fei ; Sun, Wei ; Xia, Kai ; Madar, Vered ; Jansen, Rick ; Chung, Wonil ; Zhou, Yi Hui ; Abdellaoui, Abdel ; Batista, Sandra ; Butler, Casey ; Chen, Guanhua ; Chen, Ting Huei ; D'Ambrosio, David ; Gallins, Paul ; Ha, Min Jin ; Hottenga, Jouke Jan ; Huang, Shunping ; Kattenberg, Mathijs ; Kochar, Jaspreet ; Middeldorp, Christel M. ; Qu, Ani ; Shabalin, Andrey ; Tischfield, Jay ; Todd, Laura ; Tzeng, Jung Ying ; Van Grootheest, Gerard ; Vink, Jacqueline M. ; Wang, Qi ; Wang, Wei ; Wang, Weibo ; Willemsen, Gonneke ; Smit, Johannes H. ; De Geus, Eco J. ; Yin, Zhaoyu ; Penninx, Brenda W.J.H. ; Boomsma, Dorret I. / Heritability and genomics of gene expression in peripheral blood. In: Nature genetics. 2014 ; Vol. 46, No. 5. pp. 430-437.
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Wright, FA, Sullivan, PF, Brooks, AI, Zou, F, Sun, W, Xia, K, Madar, V, Jansen, R, Chung, W, Zhou, YH, Abdellaoui, A, Batista, S, Butler, C, Chen, G, Chen, TH, D'Ambrosio, D, Gallins, P, Ha, MJ, Hottenga, JJ, Huang, S, Kattenberg, M, Kochar, J, Middeldorp, CM, Qu, A, Shabalin, A, Tischfield, J, Todd, L, Tzeng, JY, Van Grootheest, G, Vink, JM, Wang, Q, Wang, W, Wang, W, Willemsen, G, Smit, JH, De Geus, EJ, Yin, Z, Penninx, BWJH & Boomsma, DI 2014, 'Heritability and genomics of gene expression in peripheral blood', Nature genetics, vol. 46, no. 5, pp. 430-437. https://doi.org/10.1038/ng.2951

Heritability and genomics of gene expression in peripheral blood. / Wright, Fred A.; Sullivan, Patrick F.; Brooks, Andrew I.; Zou, Fei; Sun, Wei; Xia, Kai; Madar, Vered; Jansen, Rick; Chung, Wonil; Zhou, Yi Hui; Abdellaoui, Abdel; Batista, Sandra; Butler, Casey; Chen, Guanhua; Chen, Ting Huei; D'Ambrosio, David; Gallins, Paul; Ha, Min Jin; Hottenga, Jouke Jan; Huang, Shunping; Kattenberg, Mathijs; Kochar, Jaspreet; Middeldorp, Christel M.; Qu, Ani; Shabalin, Andrey; Tischfield, Jay; Todd, Laura; Tzeng, Jung Ying; Van Grootheest, Gerard; Vink, Jacqueline M.; Wang, Qi; Wang, Wei; Wang, Weibo; Willemsen, Gonneke; Smit, Johannes H.; De Geus, Eco J.; Yin, Zhaoyu; Penninx, Brenda W.J.H.; Boomsma, Dorret I.

In: Nature genetics, Vol. 46, No. 5, 05.2014, p. 430-437.

Research output: Contribution to journalArticle

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AU - Wright, Fred A.

AU - Sullivan, Patrick F.

AU - Brooks, Andrew I.

AU - Zou, Fei

AU - Sun, Wei

AU - Xia, Kai

AU - Madar, Vered

AU - Jansen, Rick

AU - Chung, Wonil

AU - Zhou, Yi Hui

AU - Abdellaoui, Abdel

AU - Batista, Sandra

AU - Butler, Casey

AU - Chen, Guanhua

AU - Chen, Ting Huei

AU - D'Ambrosio, David

AU - Gallins, Paul

AU - Ha, Min Jin

AU - Hottenga, Jouke Jan

AU - Huang, Shunping

AU - Kattenberg, Mathijs

AU - Kochar, Jaspreet

AU - Middeldorp, Christel M.

AU - Qu, Ani

AU - Shabalin, Andrey

AU - Tischfield, Jay

AU - Todd, Laura

AU - Tzeng, Jung Ying

AU - Van Grootheest, Gerard

AU - Vink, Jacqueline M.

AU - Wang, Qi

AU - Wang, Wei

AU - Wang, Weibo

AU - Willemsen, Gonneke

AU - Smit, Johannes H.

AU - De Geus, Eco J.

AU - Yin, Zhaoyu

AU - Penninx, Brenda W.J.H.

AU - Boomsma, Dorret I.

PY - 2014/5

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