Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene

Niall P. Murphy; Hoa A. Lam; Zhenping Chen; John E. Pintar; Nigel T. Maidment

doi:10.1016/S0006-8993(02)03398-X

Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene

Niall P. Murphy, Hoa A. Lam, Zhenping Chen, John E. Pintar, Nigel T. Maidment

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22 Scopus citations

Abstract

We sought evidence for a role of endogenous nociceptin in modulating opiate effects on locomotion and mesolimbic dopamine release. Heroin administration (1, 3 and 10 mg/kg) induced dose-dependent increases in locomotion and mesolimbic dopamine release. However, no differences were identified between wild-type and nociceptin receptor-deficient mice, suggesting that either these systems are not influenced by an endogenous nociceptin tone, or that compensatory mechanisms activated during development normalize the response.

Original language	English (US)
Pages (from-to)	276-280
Number of pages	5
Journal	Brain research
Volume	953
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)03398-X
State	Published - Nov 20 2002

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Dopamine
Locomotion
Mesolimbic
Nociceptin
Opiate
Orphanin FQ

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10.1016/S0006-8993(02)03398-X

Cite this

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title = "Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene",

abstract = "We sought evidence for a role of endogenous nociceptin in modulating opiate effects on locomotion and mesolimbic dopamine release. Heroin administration (1, 3 and 10 mg/kg) induced dose-dependent increases in locomotion and mesolimbic dopamine release. However, no differences were identified between wild-type and nociceptin receptor-deficient mice, suggesting that either these systems are not influenced by an endogenous nociceptin tone, or that compensatory mechanisms activated during development normalize the response.",

keywords = "Dopamine, Locomotion, Mesolimbic, Nociceptin, Opiate, Orphanin FQ",

author = "Murphy, {Niall P.} and Lam, {Hoa A.} and Zhenping Chen and Pintar, {John E.} and Maidment, {Nigel T.}",

note = "Funding Information: This work was supported by NIDA grants #DA05010, #DA09359 and #DA09040.",

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T1 - Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene

AU - Murphy, Niall P.

AU - Lam, Hoa A.

AU - Chen, Zhenping

AU - Pintar, John E.

AU - Maidment, Nigel T.

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PY - 2002/11/20

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N2 - We sought evidence for a role of endogenous nociceptin in modulating opiate effects on locomotion and mesolimbic dopamine release. Heroin administration (1, 3 and 10 mg/kg) induced dose-dependent increases in locomotion and mesolimbic dopamine release. However, no differences were identified between wild-type and nociceptin receptor-deficient mice, suggesting that either these systems are not influenced by an endogenous nociceptin tone, or that compensatory mechanisms activated during development normalize the response.

AB - We sought evidence for a role of endogenous nociceptin in modulating opiate effects on locomotion and mesolimbic dopamine release. Heroin administration (1, 3 and 10 mg/kg) induced dose-dependent increases in locomotion and mesolimbic dopamine release. However, no differences were identified between wild-type and nociceptin receptor-deficient mice, suggesting that either these systems are not influenced by an endogenous nociceptin tone, or that compensatory mechanisms activated during development normalize the response.

KW - Dopamine

KW - Locomotion

KW - Mesolimbic

KW - Nociceptin

KW - Opiate

KW - Orphanin FQ

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Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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