Abstract
Heterochromatin is a specialized form of chromosomal material (chromatin) that impacts gene silencing and chromosome function. Its structure is determined by the interplay between specific histone modifications, chromatin modifiers, and effector proteins, guided by noncoding RNA, RNA interference, and DNA methylation. Recently, novel insights into the establishment, maintenance, and spreading of heterochromatin have revealed a highly dynamic regulation during the cell cycle, as well as interactions with DNA replication, recombination, and repair.
| Original language | English (US) |
|---|---|
| Title of host publication | Brenner's Encyclopedia of Genetics |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 438-441 |
| Number of pages | 4 |
| ISBN (Electronic) | 9780080961569 |
| ISBN (Print) | 9780123749840 |
| DOIs | |
| State | Published - Feb 27 2013 |
All Science Journal Classification (ASJC) codes
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology
- General Medicine
Keywords
- Acetylation
- Centromere
- Chromosome
- Cohesin
- Euchromatin
- Heterochromatin
- Methylation
- RDNA
- RNAi
- Repeat
- SRNA
- Satellite
- Telomere
- Transposable Elements
- Variegation
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