Abstract
There are many lines of evidence indicating that oligodendrocyte progenitor cells and oligodendrocyte populations in the central nervous system (CNS) are heterogeneous based on their developmental origins as well as from morphological and molecular criteria. Whether these distinctions reflect functional heterogeneity is less clear and has been the subject of considerable debate. Recent findings, particularly from knockout mouse models, have provided new evidence for regional variations in myelination phenotypes, particularly between brain and spinal cord. These data raise the possibility that oligodendrocytes in these regions have different functional capacities and/or ability to compensate for loss of a specific gene. The goal of this review is to briefly revisit the evidence for oligodendrocyte heterogeneity and then to present data from transgenic and demyelinating mouse models suggesting functional heterogeneity in myelination, demyelination, and remyelination in the CNS and, finally, to discuss the implications of these findings for human diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1421-1433 |
| Number of pages | 13 |
| Journal | Journal of Neuroscience Research |
| Volume | 94 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2016 |
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All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
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Heterogeneity in oligodendroglia : Is it relevant to mouse models and human disease? / Ornelas, Isis M.; McLane, Lauren E.; Saliu, Aminat; Evangelou, Angelina V.; Khandker, Luipa; Wood, Teresa.
In: Journal of Neuroscience Research, Vol. 94, No. 12, 01.12.2016, p. 1421-1433.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Heterogeneity in oligodendroglia
T2 - Is it relevant to mouse models and human disease?
AU - Ornelas, Isis M.
AU - McLane, Lauren E.
AU - Saliu, Aminat
AU - Evangelou, Angelina V.
AU - Khandker, Luipa
AU - Wood, Teresa
PY - 2016/12/1
Y1 - 2016/12/1
N2 - There are many lines of evidence indicating that oligodendrocyte progenitor cells and oligodendrocyte populations in the central nervous system (CNS) are heterogeneous based on their developmental origins as well as from morphological and molecular criteria. Whether these distinctions reflect functional heterogeneity is less clear and has been the subject of considerable debate. Recent findings, particularly from knockout mouse models, have provided new evidence for regional variations in myelination phenotypes, particularly between brain and spinal cord. These data raise the possibility that oligodendrocytes in these regions have different functional capacities and/or ability to compensate for loss of a specific gene. The goal of this review is to briefly revisit the evidence for oligodendrocyte heterogeneity and then to present data from transgenic and demyelinating mouse models suggesting functional heterogeneity in myelination, demyelination, and remyelination in the CNS and, finally, to discuss the implications of these findings for human diseases.
AB - There are many lines of evidence indicating that oligodendrocyte progenitor cells and oligodendrocyte populations in the central nervous system (CNS) are heterogeneous based on their developmental origins as well as from morphological and molecular criteria. Whether these distinctions reflect functional heterogeneity is less clear and has been the subject of considerable debate. Recent findings, particularly from knockout mouse models, have provided new evidence for regional variations in myelination phenotypes, particularly between brain and spinal cord. These data raise the possibility that oligodendrocytes in these regions have different functional capacities and/or ability to compensate for loss of a specific gene. The goal of this review is to briefly revisit the evidence for oligodendrocyte heterogeneity and then to present data from transgenic and demyelinating mouse models suggesting functional heterogeneity in myelination, demyelination, and remyelination in the CNS and, finally, to discuss the implications of these findings for human diseases.
UR - http://www.scopus.com/inward/record.url?scp=84991662097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991662097&partnerID=8YFLogxK
U2 - 10.1002/jnr.23900
DO - 10.1002/jnr.23900
M3 - Review article
C2 - 27557736
AN - SCOPUS:84991662097
VL - 94
SP - 1421
EP - 1433
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
SN - 0360-4012
IS - 12
ER -