Heterogeneity in oligodendroglia: Is it relevant to mouse models and human disease?

Isis M. Ornelas, Lauren E. McLane, Aminat Saliu, Angelina V. Evangelou, Luipa Khandker, Teresa Wood

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

There are many lines of evidence indicating that oligodendrocyte progenitor cells and oligodendrocyte populations in the central nervous system (CNS) are heterogeneous based on their developmental origins as well as from morphological and molecular criteria. Whether these distinctions reflect functional heterogeneity is less clear and has been the subject of considerable debate. Recent findings, particularly from knockout mouse models, have provided new evidence for regional variations in myelination phenotypes, particularly between brain and spinal cord. These data raise the possibility that oligodendrocytes in these regions have different functional capacities and/or ability to compensate for loss of a specific gene. The goal of this review is to briefly revisit the evidence for oligodendrocyte heterogeneity and then to present data from transgenic and demyelinating mouse models suggesting functional heterogeneity in myelination, demyelination, and remyelination in the CNS and, finally, to discuss the implications of these findings for human diseases.

Original languageEnglish (US)
Pages (from-to)1421-1433
Number of pages13
JournalJournal of Neuroscience Research
Volume94
Issue number12
DOIs
StatePublished - Dec 1 2016

Fingerprint

Oligodendroglia
Central Nervous System
Demyelinating Diseases
Knockout Mice
Transgenic Mice
Spinal Cord
Stem Cells
Phenotype
Brain
Population
Genes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

Ornelas, Isis M. ; McLane, Lauren E. ; Saliu, Aminat ; Evangelou, Angelina V. ; Khandker, Luipa ; Wood, Teresa. / Heterogeneity in oligodendroglia : Is it relevant to mouse models and human disease?. In: Journal of Neuroscience Research. 2016 ; Vol. 94, No. 12. pp. 1421-1433.
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Ornelas, IM, McLane, LE, Saliu, A, Evangelou, AV, Khandker, L & Wood, T 2016, 'Heterogeneity in oligodendroglia: Is it relevant to mouse models and human disease?', Journal of Neuroscience Research, vol. 94, no. 12, pp. 1421-1433. https://doi.org/10.1002/jnr.23900

Heterogeneity in oligodendroglia : Is it relevant to mouse models and human disease? / Ornelas, Isis M.; McLane, Lauren E.; Saliu, Aminat; Evangelou, Angelina V.; Khandker, Luipa; Wood, Teresa.

In: Journal of Neuroscience Research, Vol. 94, No. 12, 01.12.2016, p. 1421-1433.

Research output: Contribution to journalReview article

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