Heterophilic interactions of the neural cell adhesion molecules Ng-CAM and Nr-CAM with neural receptors and extracellular matrix proteins

Martin Grumet, Takeshi Sakurai

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Ng-CAM/L1 and Nr-CAM are closely related neural cell adhesion molecules expressed on neurons and Schwann cells. Ng-CAM/L1 is prevalent on axons and is a potent promoter of neurite growth and axonal fasciculation. Although Nr-CAM does not appear to play a major role in these functions, its transient expression in the developing-floor plate of the spinal cord is important for guidance of commissural axons. Ng-CAM and Nr-CAM can bind homophilicly and heterophilicly to several adhesion molecules. Different complexes of adhesion molecules are likely to control axonal growth and guidance as a consequence of their differential localizations in vivo.

Original languageEnglish (US)
Pages (from-to)379-389
Number of pages11
JournalSeminars in the Neurosciences
Volume8
Issue number6
DOIs
StatePublished - Dec 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Cell adhesion molecules
  • Extracellular matrix
  • L1
  • Ng-CAM
  • Nr-CAM

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