High-Fidelity Modeling of Human Microglia with Pluripotent Stem Cells

Peng Jiang, Luka Turkalj, Ranjie Xu

Research output: Contribution to journalComment/debatepeer-review

9 Scopus citations

Abstract

Gosselin et al. (2017) reported that a tissue-environment-dependent transcriptional network specifies human microglia identity and that in vitro environments drastically alter the human microglia transcriptome. Recent 3-dimensional culture and human-mouse chimeric brain modeling systems developed using human pluripotent stem cells help us understand the complex properties of human microglia.

Original languageEnglish (US)
Pages (from-to)629-631
Number of pages3
JournalCell Stem Cell
Volume26
Issue number5
DOIs
StatePublished - May 7 2020

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Cell Biology

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