High Frequency Ultrasound Prediction of Mechanical Properties of Cortical Bone with Varying Amount of Mineral Content

Shiva P. Kotha, Carl Alex DePaula, Adrian B. Mann, Nejat Guzelsu

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8 Scopus citations


In this study, we evaluate if high frequency ultrasound impedance measurements can predict the mechanical properties of bones where the amount of bone mineral is varied. The motivation stems from the potential utility of ultrasound as a noninvasive technique to evaluate and monitor the mechanical properties of bone during treatment of diseased states where the ratio of mineral content to organic matrix content could change (e.g., metabolic bone diseases, osteoarthritis, osteogenesis imperfecta, fracture healing). Eleven cortical bovine femur samples, which were taken along the long axis of femur, were used in each group. Bone samples with reduced mineral content (estimated to be 21% and 35% less than the control) were obtained by immersing samples into fluoride ion solution for 3 and 12 d. Control and fluoride treated samples were first tested mechanically in tension. Acoustic impedances of the mechanically tested samples were obtained by using scanning acoustic microscopy (SAM). Results from mechanical tests indicate that the tensile elastic modulus of the samples was highly correlated to the yield strength (r2 = 0.94, p < 0.01) and to the ultimate strength (r2 = 0.75, p < 0.01). SAM results indicate that the acoustic impedances were significantly correlated to the elastic modulus (r2 = 0.85, p < 0.01), yield strength (r2 = 0.86, p < 0.01) and ultimate strength (r2 = 0.70, p < 0.01). These results show that ultrasonic techniques could potentially be used to predict the in vivo ultimate strength of bone tissue caused by changes in mineral content. (E-mail: guzelsu@umdnj.edu).

Original languageEnglish (US)
Pages (from-to)630-637
Number of pages8
JournalUltrasound in Medicine and Biology
Issue number4
StatePublished - Apr 2008

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics


  • Acoustic impedance
  • Cortical bone
  • Elastic modulus
  • Scanning acoustic microscopy
  • Ultimate strength


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