High sensitivity handheld analog readout circuit for microfluidic based electrical impedance sensing

Niloy Talukder, Tuan Le, Pengfei Xie, Steve Orbine, Xinnan Cao, Mehdi Javanmard

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we present a novel lock-in-amplifier design analog readout of a microfluidic based impedance cytometer which is portable, low cost and capable of detecting 8 micron bead with a signal to noise ratio (SNR) of 184. Phase mismatch between sensor signal and the reference signal, which is a major concern in lock-in-amplifier design does not pose any problem in our detection technique. The circuit board was tested with gold electrodes micro-patterned on a glass substrate. This design can be further improved for submicron biological cell characterization and detection while we can miniaturize the circuit size and reduce cost significantly.

Original languageEnglish (US)
Title of host publication2015 IEEE Signal Processing in Medicine and Biology Symposium - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781509013500
DOIs
StatePublished - Feb 11 2016
EventIEEE Signal Processing in Medicine and Biology Symposium - Philadelphia, United States
Duration: Dec 12 2015 → …

Publication series

Name2015 IEEE Signal Processing in Medicine and Biology Symposium - Proceedings

Other

OtherIEEE Signal Processing in Medicine and Biology Symposium
CountryUnited States
CityPhiladelphia
Period12/12/15 → …

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Signal Processing
  • Radiology Nuclear Medicine and imaging
  • Health Informatics

Keywords

  • analog lock in amplifier
  • biochip
  • impedance cytometer
  • microfluidics

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