High yield protection of purine ribonucleosides for H-phosphonate RNA synthesis

Xiaohu Zhang; José Luis Abad; Qingtao Huang; Fan Zeng; Barbara L. Gaffney; Roger A. Jones

doi:10.1016/S0040-4039(97)01767-X

High yield protection of purine ribonucleosides for H-phosphonate RNA synthesis

Xiaohu Zhang, José Luis Abad, Qingtao Huang, Fan Zeng, Barbara L. Gaffney, Roger A. Jones

School of Arts and Sciences, Chemistry & Chemical Biology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We report a new method for protecting nucleosides for hydrogen phosphonate RNA synthesis that gives very high yields for the purines. This method is based on our finding that, for adenosine and guanosine, silylation of a mixture of 2' and 3'H-phosphonates in the presence of DBU is highly selective for the 2' hydroxyl.

Original language	English (US)
Pages (from-to)	7135-7138
Number of pages	4
Journal	Tetrahedron Letters
Volume	38
Issue number	41
DOIs	https://doi.org/10.1016/S0040-4039(97)01767-X
State	Published - Oct 13 1997

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)01767-X

Cite this

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abstract = "We report a new method for protecting nucleosides for hydrogen phosphonate RNA synthesis that gives very high yields for the purines. This method is based on our finding that, for adenosine and guanosine, silylation of a mixture of 2' and 3'H-phosphonates in the presence of DBU is highly selective for the 2' hydroxyl.",

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T1 - High yield protection of purine ribonucleosides for H-phosphonate RNA synthesis

AU - Zhang, Xiaohu

AU - Abad, José Luis

AU - Huang, Qingtao

AU - Zeng, Fan

AU - Gaffney, Barbara L.

AU - Jones, Roger A.

PY - 1997/10/13

Y1 - 1997/10/13

N2 - We report a new method for protecting nucleosides for hydrogen phosphonate RNA synthesis that gives very high yields for the purines. This method is based on our finding that, for adenosine and guanosine, silylation of a mixture of 2' and 3'H-phosphonates in the presence of DBU is highly selective for the 2' hydroxyl.

AB - We report a new method for protecting nucleosides for hydrogen phosphonate RNA synthesis that gives very high yields for the purines. This method is based on our finding that, for adenosine and guanosine, silylation of a mixture of 2' and 3'H-phosphonates in the presence of DBU is highly selective for the 2' hydroxyl.

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JO - Tetrahedron Letters

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ER -

High yield protection of purine ribonucleosides for H-phosphonate RNA synthesis

Abstract

All Science Journal Classification (ASJC) codes

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