Hippo signaling goes long range

Veronica A. Codelia, Kenneth D. Irvine

Research output: Contribution to journalShort surveypeer-review

22 Scopus citations

Abstract

The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.

Original languageEnglish (US)
Pages (from-to)669-670
Number of pages2
JournalCell
Volume150
Issue number4
DOIs
StatePublished - Aug 17 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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