Histidine kinases and response regulator proteins in two-component signaling systems

Ann H. West, Ann M. Stock

Research output: Contribution to journalReview articlepeer-review

718 Scopus citations

Abstract

Phosphotransfer-mediated signaling pathways allow cells to sense and respond to environmental stimuli. Autophosphorylating histidine protein kinases provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. Structural studies of proteins involved in two-component signaling systems have revealed a modular architecture with versatile conserved domains that are readily adapted to the specific needs of individual systems.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalTrends in Biochemical Sciences
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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