Alloimmunization represents the major complication of platelet transfusion therapy. In the late 1960s it was first reported that platelets from both family members and nonrelated donors matched at the HLA A and B loci could circulate normally in some recipients who were otherwise refractory to platelet transfusions from nonmatched donors. Since that time, large pools of HLA-typed donors have been developed in many centers to help provide platelet transfusion support for such alloimmunized patients. It has recently been recognized that a significant percentage of either fully or partially HLA-matched transfusions are ineffective. Because of the considerable expense and effort required for donor recruitment, platelet collection, HLA typing, and computer utilization, it is important to refine donor selection further by HLA typing, and possibly to supplement HLA typing with other cross-matching techniques.
|Original language||English (US)|
|Number of pages||9|
|Journal||Plasma Therapy and Transfusion Technology|
|State||Published - 1982|
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