Histologic examination of removed transplanted kidneys

N. Ende, J. C. Pierce

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Abstract

A retrospective study is being conducted on all kidneys exchanged between institutions affiliated with the Southeastern Regional Organ Procurement Program. After having been nephrectomized or removed at autopsy, the first 76 kidneys of this study were histologically examined without knowledge of the clinical history. Vascular, glomerular, cellular infiltration and other morphologic changes were evaluated and the degree of morphologic alteration was graded from I to IV. While 39 kidneys showed adequate histologic evidence of rejection by the recipient, 9 kidneys showed morphologic changes which made the relation to the rejection hypothesis ambiguous. Twenty eight kidneys did not show sufficient histologic change to support the necessity for removal due to rejection by the host. Of this latter group of minimal or no histologic evidence of rejection, 11 were nephrectomized and 17 were obtained at autopsy. The study suggests that a significant number of transplanted cadaver kidneys were lost from causes other than rejection.

Original languageEnglish (US)
Pages (from-to)No. 134
JournalAmerican Journal of Pathology
Volume78
Issue number1
StatePublished - Jan 1 1975

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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