Histones, HMG, HU, IHF: Même combat

J. Oberto, K. Drlica, J. Rouvière-Yaniv

Research output: Contribution to journalArticle

87 Scopus citations


In this review article we present a compilation of the proteins homologous to Escherichia coli HU: the HU-like family. Two of these, HU and IHF from E coli have been extensively characterized genetically and biochemically. Due to their DNA binding activities, these proteins confer a condensed shape to the chromosome and regulate the transcription of selected sets of its genes. The parallel between the dual function of the HU-like proteins and the roles described for eukaryotic histone and HMG proteins is striking, especially in the view that they are evolutionary unrelated.

Original languageEnglish (US)
Pages (from-to)901-908
Number of pages8
Issue number10-11
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry


  • HMG
  • HU
  • IHF
  • TF1
  • histones

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