Holothurin. I. The Isolation, Properties and Sugar Components of Holothurin A1

J. D. Chanley, Robert Ledeen, J. Wax, R. F. Nigrelli, Harry Sobotka

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The isolation, properties and sugar components of holothurin A, the toxic principle of Actinopyga agassizi, a sea-cucumber found in the Bahama Islands are described. Elementary analysis of holothurin A leads to the empirical formula C50.2Hsi-5-O25-6SNa. The hydrolysis products derived from holothurin A suggest that it is a mixture of several glycosides, each of which contains a steroid aglycone of ca. 28-28 carbon and 4-5 oxygen atoms, one molecule each of four different sugars and one molecule of sulfuric acid as the sodium salt. The separation and identification of the monoses derived from holothurin A has been achieved. They were D-glucose, d-xylose, D-glucomethylose (quinovose) and 3-O-methylglucose. The neurotoxic, hemolytic and cancerostatic properties of holothurin A are referred to.

Original languageEnglish (US)
Pages (from-to)5180-5183
Number of pages4
JournalJournal of the American Chemical Society
Volume81
Issue number19
DOIs
StatePublished - Jan 1 1959
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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