Holothurin. I. The Isolation, Properties and Sugar Components of Holothurin A1

J. D. Chanley, Robert Ledeen, J. Wax, R. F. Nigrelli, Harry Sobotka

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The isolation, properties and sugar components of holothurin A, the toxic principle of Actinopyga agassizi, a sea-cucumber found in the Bahama Islands are described. Elementary analysis of holothurin A leads to the empirical formula C50.2Hsi-5-O25-6SNa. The hydrolysis products derived from holothurin A suggest that it is a mixture of several glycosides, each of which contains a steroid aglycone of ca. 28-28 carbon and 4-5 oxygen atoms, one molecule each of four different sugars and one molecule of sulfuric acid as the sodium salt. The separation and identification of the monoses derived from holothurin A has been achieved. They were D-glucose, d-xylose, D-glucomethylose (quinovose) and 3-O-methylglucose. The neurotoxic, hemolytic and cancerostatic properties of holothurin A are referred to.

Original languageEnglish (US)
Pages (from-to)5180-5183
Number of pages4
JournalJournal of the American Chemical Society
Volume81
Issue number19
DOIs
StatePublished - Jan 1 1959
Externally publishedYes

Fingerprint

Holothurin
Sugars
Glycosides
Molecules
Xylose
Sulfuric acid
Glucose
Hydrolysis
Sodium
Salts
Bahamas
Atoms
Carbon
Oxygen
Sea Cucumbers
3-O-Methylglucose
Poisons
Islands
Steroids
holothurin A1

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Chanley, J. D. ; Ledeen, Robert ; Wax, J. ; Nigrelli, R. F. ; Sobotka, Harry. / Holothurin. I. The Isolation, Properties and Sugar Components of Holothurin A1. In: Journal of the American Chemical Society. 1959 ; Vol. 81, No. 19. pp. 5180-5183.
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Holothurin. I. The Isolation, Properties and Sugar Components of Holothurin A1. / Chanley, J. D.; Ledeen, Robert; Wax, J.; Nigrelli, R. F.; Sobotka, Harry.

In: Journal of the American Chemical Society, Vol. 81, No. 19, 01.01.1959, p. 5180-5183.

Research output: Contribution to journalArticle

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AU - Ledeen, Robert

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AB - The isolation, properties and sugar components of holothurin A, the toxic principle of Actinopyga agassizi, a sea-cucumber found in the Bahama Islands are described. Elementary analysis of holothurin A leads to the empirical formula C50.2Hsi-5-O25-6SNa. The hydrolysis products derived from holothurin A suggest that it is a mixture of several glycosides, each of which contains a steroid aglycone of ca. 28-28 carbon and 4-5 oxygen atoms, one molecule each of four different sugars and one molecule of sulfuric acid as the sodium salt. The separation and identification of the monoses derived from holothurin A has been achieved. They were D-glucose, d-xylose, D-glucomethylose (quinovose) and 3-O-methylglucose. The neurotoxic, hemolytic and cancerostatic properties of holothurin A are referred to.

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