The isolation, properties and sugar components of holothurin A, the toxic principle of Actinopyga agassizi, a sea-cucumber found in the Bahama Islands are described. Elementary analysis of holothurin A leads to the empirical formula C50.2Hsi-5-O25-6SNa. The hydrolysis products derived from holothurin A suggest that it is a mixture of several glycosides, each of which contains a steroid aglycone of ca. 28-28 carbon and 4-5 oxygen atoms, one molecule each of four different sugars and one molecule of sulfuric acid as the sodium salt. The separation and identification of the monoses derived from holothurin A has been achieved. They were D-glucose, d-xylose, D-glucomethylose (quinovose) and 3-O-methylglucose. The neurotoxic, hemolytic and cancerostatic properties of holothurin A are referred to.
All Science Journal Classification (ASJC) codes
- Colloid and Surface Chemistry