Research output: Chapter in Book/Report/Conference proceedingChapter


Homocysteine is a sulfur amino acid and product of methionine metabolism. The metabolism of homocysteine requires the B-vitamins, folate, B12, B6, and riboflavin. Disruption of homocysteine metabolism due to B-vitamin deficiencies, genetic defects, or other pathophysiological conditions leads to elevation of homocysteine in the blood (hyperhomocysteinemia). Hyperhomocysteinemia is a risk factor for vascular disease, neurodegenerative disease, and other clinical conditions. B vitamin supplements are effective in lowering blood homocysteine concentration, but there is uncertainty if such supplements reduce the risk of vascular disease, age-related cognitive decline, or Alzheimer's disease/dementia.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Human Nutrition
Subtitle of host publicationVolume 1-4, Fourth Edition
Number of pages9
ISBN (Electronic)9780323908160
StatePublished - Jan 1 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Agricultural and Biological Sciences


  • Alzheimer's disease
  • Cardiovascular disease
  • Cerebrovascular disease
  • Cystathionine ß-synthase
  • Dementia
  • Folate
  • Homocysteine
  • Methionine
  • Methylenetetrahydrofolate reductase
  • Riboflavin
  • S-adenosylhomocysteine
  • S-adenosylmethionine
  • Vitamin B12
  • Vitamin B6


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