Homocysteine, folate deficiency, and Parkinson's disease

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31 Scopus citations


Folate deficiency sensitizes mice to dopaminergic neurodegeneration and motor dysfunction caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Additional experiments indicate that this effect of folate deficiency may be mediated by homocysteine. These findings suggest that folate deficiency and hyperhomocysteinemia are risk factors for Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)410-413
Number of pages4
JournalNutrition Reviews
Issue number12
StatePublished - Dec 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


  • Folate deficiency
  • Homocysteine
  • MPTP
  • Neurodegeneration
  • Parkinson's disease


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