Homocysteine, folate deficiency, and Parkinson's disease

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Folate deficiency sensitizes mice to dopaminergic neurodegeneration and motor dysfunction caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Additional experiments indicate that this effect of folate deficiency may be mediated by homocysteine. These findings suggest that folate deficiency and hyperhomocysteinemia are risk factors for Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)410-413
Number of pages4
JournalNutrition Reviews
Volume60
Issue number12
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Keywords

  • Folate deficiency
  • Homocysteine
  • MPTP
  • Neurodegeneration
  • Parkinson's disease

Fingerprint

Dive into the research topics of 'Homocysteine, folate deficiency, and Parkinson's disease'. Together they form a unique fingerprint.

Cite this