Homonymous field defect as the first manifestation of Creutzfeldt-Jakob disease

M. E. Vargas, M. J. Kupersmith, P. J. Savino, F. Petito, L. P. Frohman, F. A. Warren

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

PURPOSE: Although in the early stage of Creutzfeldt-Jakob disease most patients have obvious dementia, we found that the disease can be diagnosed in patients solely on the basis of a visual system disorder. METHODS: We examined three patients who initially complained of a nonspecific, insidious visual disturbance. RESULTS: The three patients were found to have Creutzfeldt-Jakob disease, confirmed by histopathologic analysis. Each patient had a homonymous hemianopsia on the first neuro-ophthalmologic examination. The initial neurologic, neuroimaging, and electrophysiologic examinations were not conclusive. The subsequent rapid deterioration in the neurologic status, including dementia and typical electroencephalographic changes, was suggestive of Creutzfeldt-Jakob disease. CONCLUSION: At onset of Creutzfeldt-Jakob disease, patients may have a homonymous hemianopsia despite normal results of magnetic resonance imaging of the brain and neurologic examination.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalAmerican journal of ophthalmology
Volume119
Issue number4
DOIs
StatePublished - Jan 1 1995

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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