How long should telomeres be?

Abraham Aviv, Calvin B. Harley

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

What began as a study of the "end-replication problem" took on a new dimension as it became clear that telomeres are a "molecular clock" of replication in human somatic cells. Here we review the biology of telomeres in vitro and in vivo, in mice and humans. We suggest that, in humans, telomeres are involved in the biology of aging and pathobiology of disorders of aging, including cancer and cardiovascular disease. We also propose that the underlying dynamics of telomere biology is in line with broad principles of evolutionary theories.

Original languageEnglish (US)
Pages (from-to)145-151
Number of pages7
JournalCurrent Hypertension Reports
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2001

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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