How Many Cell Types Are in the Kidney and What Do They Do?

Michael S. Balzer, Tibor Rohacs, Katalin Susztak

Research output: Contribution to journalReview articlepeer-review

Abstract

The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 different highly specialized epithelial cell types in the mammalian kidney. The number of specialized endothelial cells, immune cells, and interstitial cell types might even be larger. The concerted interplay between different cell types is critical for kidney function. Traditionally, cells were defined by their function or microscopical morphological appearance. With the advent of new single-cell modalities such as transcriptomics, epigenetics, metabolomics, and proteomics we are entering into a new era of cell type definition. This new technological revolution provides new opportunities to classify cells in the kidney and understand their functions.

Original languageEnglish (US)
Pages (from-to)507-531
Number of pages25
JournalAnnual Review of Physiology
Volume84
DOIs
StatePublished - 2022

All Science Journal Classification (ASJC) codes

  • Physiology

Keywords

  • Cell plasticity
  • Kidney cell types
  • Kidney function
  • Single-cell RNA sequencing

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