How mesenchymal stem cells interact with tissue immune responses

Yufang Shi, Juanjuan Su, Arthur I. Roberts, Peishun Shou, Arnold B. Rabson, Guangwen Ren

Research output: Contribution to journalReview articlepeer-review

367 Scopus citations


Mesenchymal stem cells (MSCs), also called multipotent mesenchymal stromal cells, exist in almost all tissues and are a key cell source for tissue repair and regeneration. Under pathological conditions, such as tissue injury, these cells are mobilized towards the site of damage. Tissue damage is usually accompanied by proinflammatory factors, produced by both innate and adaptive immune responses, to which MSCs are known to respond. Indeed, recent studies have shown that there are bidirectional interactions between MSCs and inflammatory cells, which determine the outcome of MSC-mediated tissue repair processes. Although many details of these interactions remain to be elucidated, we provide here a synthesis of the current status of this newly emerging and rapidly advancing field.

Original languageEnglish (US)
Pages (from-to)136-143
Number of pages8
JournalTrends in Immunology
Issue number3
StatePublished - Mar 2012

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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