HTLV-III and Vacuolar Myelopathy

Leroy Sharer, Leon G. Epstein, Eun Sook Cho, Carol K. Petito, S. Przedborski, C. Liesnard, J. Hildebrand

Research output: Contribution to journalLetter

34 Citations (Scopus)

Abstract

To the Editor: The isolation of the retrovirus human T-cell lymphotropic virus Type III (HTLV-III) from brain, spinal cord, peripheral nerve, and cerebrospinal fluid, as reported by Ho et al. (Dec. 12 issue), 1 provides substantial support for the theory that this virus is neurotropic as well as lymphotropic. The authors report the isolation of HTLV-III from the lumbar spinal cord of a patient (their Patient 10) who had pathologically verified vacuolar myelopathy, 2 and they conclude that the vacuolar myelopathy may have been a direct result of HTLV-III infection. Our own observations suggest an alternative explanation for these findings. Figure 1 shows inflammation….

Original languageEnglish (US)
Pages (from-to)62-63
Number of pages2
JournalNew England Journal of Medicine
Volume315
Issue number1
DOIs
StatePublished - Jul 3 1986

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Spinal Cord Diseases
Spinal Cord
HIV
Retroviridae
Peripheral Nerves
HIV Infections
Cerebrospinal Fluid
Viruses
Inflammation
Brain

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sharer, L., Epstein, L. G., Cho, E. S., Petito, C. K., Przedborski, S., Liesnard, C., & Hildebrand, J. (1986). HTLV-III and Vacuolar Myelopathy. New England Journal of Medicine, 315(1), 62-63. https://doi.org/10.1056/NEJM198607033150112
Sharer, Leroy ; Epstein, Leon G. ; Cho, Eun Sook ; Petito, Carol K. ; Przedborski, S. ; Liesnard, C. ; Hildebrand, J. / HTLV-III and Vacuolar Myelopathy. In: New England Journal of Medicine. 1986 ; Vol. 315, No. 1. pp. 62-63.
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abstract = "To the Editor: The isolation of the retrovirus human T-cell lymphotropic virus Type III (HTLV-III) from brain, spinal cord, peripheral nerve, and cerebrospinal fluid, as reported by Ho et al. (Dec. 12 issue), 1 provides substantial support for the theory that this virus is neurotropic as well as lymphotropic. The authors report the isolation of HTLV-III from the lumbar spinal cord of a patient (their Patient 10) who had pathologically verified vacuolar myelopathy, 2 and they conclude that the vacuolar myelopathy may have been a direct result of HTLV-III infection. Our own observations suggest an alternative explanation for these findings. Figure 1 shows inflammation….",
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Sharer, L, Epstein, LG, Cho, ES, Petito, CK, Przedborski, S, Liesnard, C & Hildebrand, J 1986, 'HTLV-III and Vacuolar Myelopathy', New England Journal of Medicine, vol. 315, no. 1, pp. 62-63. https://doi.org/10.1056/NEJM198607033150112

HTLV-III and Vacuolar Myelopathy. / Sharer, Leroy; Epstein, Leon G.; Cho, Eun Sook; Petito, Carol K.; Przedborski, S.; Liesnard, C.; Hildebrand, J.

In: New England Journal of Medicine, Vol. 315, No. 1, 03.07.1986, p. 62-63.

Research output: Contribution to journalLetter

TY - JOUR

T1 - HTLV-III and Vacuolar Myelopathy

AU - Sharer, Leroy

AU - Epstein, Leon G.

AU - Cho, Eun Sook

AU - Petito, Carol K.

AU - Przedborski, S.

AU - Liesnard, C.

AU - Hildebrand, J.

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N2 - To the Editor: The isolation of the retrovirus human T-cell lymphotropic virus Type III (HTLV-III) from brain, spinal cord, peripheral nerve, and cerebrospinal fluid, as reported by Ho et al. (Dec. 12 issue), 1 provides substantial support for the theory that this virus is neurotropic as well as lymphotropic. The authors report the isolation of HTLV-III from the lumbar spinal cord of a patient (their Patient 10) who had pathologically verified vacuolar myelopathy, 2 and they conclude that the vacuolar myelopathy may have been a direct result of HTLV-III infection. Our own observations suggest an alternative explanation for these findings. Figure 1 shows inflammation….

AB - To the Editor: The isolation of the retrovirus human T-cell lymphotropic virus Type III (HTLV-III) from brain, spinal cord, peripheral nerve, and cerebrospinal fluid, as reported by Ho et al. (Dec. 12 issue), 1 provides substantial support for the theory that this virus is neurotropic as well as lymphotropic. The authors report the isolation of HTLV-III from the lumbar spinal cord of a patient (their Patient 10) who had pathologically verified vacuolar myelopathy, 2 and they conclude that the vacuolar myelopathy may have been a direct result of HTLV-III infection. Our own observations suggest an alternative explanation for these findings. Figure 1 shows inflammation….

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Sharer L, Epstein LG, Cho ES, Petito CK, Przedborski S, Liesnard C et al. HTLV-III and Vacuolar Myelopathy. New England Journal of Medicine. 1986 Jul 3;315(1):62-63. https://doi.org/10.1056/NEJM198607033150112