Human glycemic response and phenolic content of unsweetened cranberry juice

Ted Wilson, Ajay P. Singh, Nicholi Vorsa, Christopher D. Goettl, Katrina M. Kittleson, Cindy M. Roe, Gary M. Kastello, Frances R. Ragsdale

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

This cross-sectional study determined the phenolic composition of an over-the-counter cranberry juice (CBJ) with high-performance liquid chromatography and examined the effects of low- and normal-calorie CBJ formulations on the postprandial glycemic response in healthy humans. The CBJ used in this study contained seven phenolic acids, with 3- and 5-caffeoylquinic acid being the primary components, and 15 flavonol glycosides, with myricetin-3-galactoside and quercetin-3-galactoside being the most prevalent. CBJ proanthocyanidins consisted of three different tetramers and a heptamer, which were confirmed with matrix-assisted laser desorption ionization-time of flight-mass spectrometry analysis. Participants received one of the following six treatments: nothing (no water/beverage), water (480 mL), unsweetened low-calorie CBJ (38 Cal/480 mL), normal-calorie CBJ (280 Cal/480 mL), isocaloric normal calorie (high fructose corn syrup [HFCS]), or isocaloric low-calorie beverages. No significant differences in postprandial blood glucose or insulin were observed in the groups receiving nothing, water, or low-calorie treatments. In contrast, the ingestion of normal-calorie CBJ and normal-calorie control beverage resulted in significantly higher blood glucose concentrations 30 minutes postprandially, although the differences were no longer significant after 180 minutes. Plasma insulin of normal-calorie CBJ and control (HFCS) recipients was significantly higher 60 minutes postprandially, but not significantly different 120 minutes postprandially. CBJ ingestion did not affect heart rate or blood pressure. This study suggests that the consumption of a low-calorie CBJ rich in previously uncharacterized trimer and heptamer proanthocyanidins is associated with a favorable glycemic response and may be beneficial for persons with impaired glucose tolerance.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalJournal of medicinal food
Volume11
Issue number1
DOIs
StatePublished - Mar 1 2008

Fingerprint

Vaccinium macrocarpon
Beverages
Proanthocyanidins
Blood Glucose
Water
Eating
Insulin
Chlorogenic Acid
Galactosides
Glucose Intolerance
Glycosides
Mass Spectrometry
Lasers
Cross-Sectional Studies
Heart Rate
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Keywords

  • Blood glucose
  • Cranberry
  • Flavonoid
  • Glycemic response
  • Phenolic
  • Proanthocyanidin

Cite this

Wilson, T., Singh, A. P., Vorsa, N., Goettl, C. D., Kittleson, K. M., Roe, C. M., ... Ragsdale, F. R. (2008). Human glycemic response and phenolic content of unsweetened cranberry juice. Journal of medicinal food, 11(1), 46-54. https://doi.org/10.1089/jmf.2007.531
Wilson, Ted ; Singh, Ajay P. ; Vorsa, Nicholi ; Goettl, Christopher D. ; Kittleson, Katrina M. ; Roe, Cindy M. ; Kastello, Gary M. ; Ragsdale, Frances R. / Human glycemic response and phenolic content of unsweetened cranberry juice. In: Journal of medicinal food. 2008 ; Vol. 11, No. 1. pp. 46-54.
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Wilson, T, Singh, AP, Vorsa, N, Goettl, CD, Kittleson, KM, Roe, CM, Kastello, GM & Ragsdale, FR 2008, 'Human glycemic response and phenolic content of unsweetened cranberry juice', Journal of medicinal food, vol. 11, no. 1, pp. 46-54. https://doi.org/10.1089/jmf.2007.531

Human glycemic response and phenolic content of unsweetened cranberry juice. / Wilson, Ted; Singh, Ajay P.; Vorsa, Nicholi; Goettl, Christopher D.; Kittleson, Katrina M.; Roe, Cindy M.; Kastello, Gary M.; Ragsdale, Frances R.

In: Journal of medicinal food, Vol. 11, No. 1, 01.03.2008, p. 46-54.

Research output: Contribution to journalArticle

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