Human immunodeficiency virus infection in advanced maternal age gravidas

Kelecia Brown, Bart Holland, Claudia Mosquera, Charmane Calilap, Arlene Bardeguez

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Our study compares perinatal outcomes among HIV + versus HIV - advanced maternal aged (AMA) women. A retrospective cohort study of AMA deliveries from 2000 to 2009 was performed. HIV + (group A) women were compared to temporally matched HIV - (group B) women. Demographics, medical comorbidities, HIV treatment, and delivery data were collected. SAS was used for data analysis with p<0.05 considered significant. Seventy-one patients per study group were reviewed; for group A, the mean CD4 count near delivery was 507±363; 75% (34/45) had viral load ≤400 in the third trimester and 58% were on a protease inhibitor regimen. HIV + women had significantly higher preterm delivery (PTD) <37 weeks (A: 40.85%, B: 16.90%, p=0.0016). Logistic regression performed revealed that the odds of PTD was 2.83 (CI 1.22-6.54) for HIV + and 4.02 (CI 1.27-12.72) for drug use independent of other factors. The pathophysiology of PTD among HIV + AMA women warrants prospective examination to better define the causal relationship.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalAIDS research and human retroviruses
Volume28
Issue number3
DOIs
StatePublished - Mar 1 2012

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

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