Abstract
A novel generation of silk-based brain implants engineered to release adenosine was recently shown to provide robust seizure suppression in kindled rats. As a first step to develop stem cell-coated silk-based 3D-scaffolds for the therapeutic long-term delivery of adenosine we engineered human mesenchymal stem cells (hMSCs) to release adenosine. Here we demonstrate reduction of chronic seizures in a mouse model of CA3-selective epileptogenesis after infrahippocampal transplantation of adenosine-releasing hMSCs.
Original language | English (US) |
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Pages (from-to) | 238-241 |
Number of pages | 4 |
Journal | Epilepsy Research |
Volume | 84 |
Issue number | 2-3 |
DOIs | |
State | Published - Apr 2009 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
Keywords
- Adenosine
- Cell therapy
- Epilepsy
- Grafting
- Human mesenchymal stem cells
- Silk