Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis

Tianfu Li, Gaoying Ren, David L. Kaplan, Detlev Boison

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

A novel generation of silk-based brain implants engineered to release adenosine was recently shown to provide robust seizure suppression in kindled rats. As a first step to develop stem cell-coated silk-based 3D-scaffolds for the therapeutic long-term delivery of adenosine we engineered human mesenchymal stem cells (hMSCs) to release adenosine. Here we demonstrate reduction of chronic seizures in a mouse model of CA3-selective epileptogenesis after infrahippocampal transplantation of adenosine-releasing hMSCs.

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalEpilepsy Research
Volume84
Issue number2-3
DOIs
StatePublished - Apr 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Keywords

  • Adenosine
  • Cell therapy
  • Epilepsy
  • Grafting
  • Human mesenchymal stem cells
  • Silk

Fingerprint

Dive into the research topics of 'Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis'. Together they form a unique fingerprint.

Cite this