Human natural cytotoxic activity mediated by tumor necrosis factor: Regulation by interleukin-2

Edmund C. Lattime, Antonella Stoppacciaro, Amanullah Khan, Osias Stutman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Freshly obtained normal lymphoid cells kill certain tumor target cells in vitro. Using peripheral-blood lymphocytes (PBLs) and the human tumor target cell line BT-20, we have defined a tumor necrosis factor (TNF)-dependent, cell-mediated cytotoxic mechanism that is homologous to the murine natural cytotoxic (NC) cell activity. Human NC cell activity was detected in freshly isolated PBLs and was augmented by short in vitro pulses with recombinant human interleudin-2 but not with recombinant human alfa interferon. Monoclonal anti-TNF antibodies inhibited the killing of the target cells. The independence of interferon and the mediation of killing by TNF distinguish human NC cell activity from natural killer and lymphokine-activated killer cell activitoes. [J Natl Cancer Inst 1988;80:1035-1038].

Original languageEnglish (US)
Pages (from-to)1035-1038
Number of pages4
JournalJournal of the National Cancer Institute
Volume80
Issue number13
DOIs
StatePublished - Sep 7 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Human natural cytotoxic activity mediated by tumor necrosis factor: Regulation by interleukin-2'. Together they form a unique fingerprint.

  • Cite this