Human Papillomavirus Vaccination and Infection in Young Sexual Minority Men: The P18 Cohort Study

Perry N. Halkitis, Pamela Valera, Caleb E. Loschiavo, Stephen E. Goldstone, Maria Kanztanou, Anthony J. Maiolatesi, Danielle C. Ompad, Richard E. Greene, Farzana Kapadia

Research output: Contribution to journalArticle

Abstract

We examined the prevalence of infection with human papillomavirus (HPV) and HIV in a cohort of young gay, bisexual, and other men who have sex with men [sexual minority men (SMM)]. HPV vaccination uptake was assessed; HIV antibody testing was performed and genetic testing for oral and anal HPV infection was undertaken. We examined both HPV vaccination and infection in relation to key demographic and structural variables. Participants (n = 486) were on average 23 years old; 70% identified as a member of a racial/ethnic minority group, and 7% identified as transgender females. Only 18.1% of the participants indicated having received the full dosage of HPV vaccination and 45.1% were unvaccinated. Slightly over half the participants (58.6%) were infected with HPV, with 58.1% testing positive for anal infection and 8.8% for oral infection. HIV seropositivity was associated with infection to oral HPV [adjusted odds ratio (AOR) = 4.03] and vaccine-preventable HPV, whereas both neighborhood-level poverty (AOR = 1.68) and HIV infection (AOR = 31.13) were associated with anal infection to HPV (AOR = 1.68). Prevalence of HPV infection is high among unvaccinated young SMM, despite the availability and eligibility for vaccination. HPV infection adds further health burden to these populations and is particularly concerning for those who are HIV positive as HIV infection increases the risk of developing HPV-related cancers. These findings underscore a missed prevention opportunity for an at-risk and underserved population and suggest the need for active strategies to increase HPV vaccination uptake in young SMM before the onset of sexual behavior.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalAIDS patient care and STDs
Volume33
Issue number4
DOIs
StatePublished - Apr 2019

Fingerprint

Papillomavirus Infections
Vaccination
Cohort Studies
Odds Ratio
Infection
HIV Infections
Sexual Minorities
HIV
Transgender Persons
HIV Seropositivity
Papillomavirus Vaccines
Minority Groups
HIV Antibodies
Genetic Testing
Vulnerable Populations
Poverty
Ethnic Groups
Sexual Behavior
Demography

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Keywords

  • HIV
  • HPV
  • cancer
  • emerging adulthood
  • gay and bisexual men
  • vaccination

Cite this

Halkitis, Perry N. ; Valera, Pamela ; Loschiavo, Caleb E. ; Goldstone, Stephen E. ; Kanztanou, Maria ; Maiolatesi, Anthony J. ; Ompad, Danielle C. ; Greene, Richard E. ; Kapadia, Farzana. / Human Papillomavirus Vaccination and Infection in Young Sexual Minority Men : The P18 Cohort Study. In: AIDS patient care and STDs. 2019 ; Vol. 33, No. 4. pp. 149-156.
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Halkitis, PN, Valera, P, Loschiavo, CE, Goldstone, SE, Kanztanou, M, Maiolatesi, AJ, Ompad, DC, Greene, RE & Kapadia, F 2019, 'Human Papillomavirus Vaccination and Infection in Young Sexual Minority Men: The P18 Cohort Study', AIDS patient care and STDs, vol. 33, no. 4, pp. 149-156. https://doi.org/10.1089/apc.2018.0276

Human Papillomavirus Vaccination and Infection in Young Sexual Minority Men : The P18 Cohort Study. / Halkitis, Perry N.; Valera, Pamela; Loschiavo, Caleb E.; Goldstone, Stephen E.; Kanztanou, Maria; Maiolatesi, Anthony J.; Ompad, Danielle C.; Greene, Richard E.; Kapadia, Farzana.

In: AIDS patient care and STDs, Vol. 33, No. 4, 04.2019, p. 149-156.

Research output: Contribution to journalArticle

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AU - Valera, Pamela

AU - Loschiavo, Caleb E.

AU - Goldstone, Stephen E.

AU - Kanztanou, Maria

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AU - Kapadia, Farzana

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N2 - We examined the prevalence of infection with human papillomavirus (HPV) and HIV in a cohort of young gay, bisexual, and other men who have sex with men [sexual minority men (SMM)]. HPV vaccination uptake was assessed; HIV antibody testing was performed and genetic testing for oral and anal HPV infection was undertaken. We examined both HPV vaccination and infection in relation to key demographic and structural variables. Participants (n = 486) were on average 23 years old; 70% identified as a member of a racial/ethnic minority group, and 7% identified as transgender females. Only 18.1% of the participants indicated having received the full dosage of HPV vaccination and 45.1% were unvaccinated. Slightly over half the participants (58.6%) were infected with HPV, with 58.1% testing positive for anal infection and 8.8% for oral infection. HIV seropositivity was associated with infection to oral HPV [adjusted odds ratio (AOR) = 4.03] and vaccine-preventable HPV, whereas both neighborhood-level poverty (AOR = 1.68) and HIV infection (AOR = 31.13) were associated with anal infection to HPV (AOR = 1.68). Prevalence of HPV infection is high among unvaccinated young SMM, despite the availability and eligibility for vaccination. HPV infection adds further health burden to these populations and is particularly concerning for those who are HIV positive as HIV infection increases the risk of developing HPV-related cancers. These findings underscore a missed prevention opportunity for an at-risk and underserved population and suggest the need for active strategies to increase HPV vaccination uptake in young SMM before the onset of sexual behavior.

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