Human retroviral sequences on the Y chromosome

J. Silver, A. Rabson, T. Bryan, R. Willey, M. A. Martin

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Novel endogenous human retroviral sequences were cloned by low-stringency hybridization, using the pol gene of endogenous human retrovirus 51-1. One clone, λNP-2, contained gag, pol, env, and long terminal repeat sequences related to the corresponding portions of clone 51-1 and the closely related full-length endogenous human retrovirus 4-1. The sequence of the env gene of NP-2 was 73% homologous to that of 4-1. Genomic Southern blots of male and female DNAs showed that NP-2 is located on the Y chromosome and that the Y chromosome also contains one other sequence closely related to the env and 3, flanking regions of NP-2. Conservation of flanking DNA suggests that the second Y chromosome copy of the NP-2 env sequence arose by gene duplication rather than provirus insertion.

Original languageEnglish (US)
Pages (from-to)1559-1562
Number of pages4
JournalMolecular and cellular biology
Issue number4
StatePublished - 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology


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