Hydration and partial compressibility of biological compounds

Tigran V. Chalikian, Armen P. Sarvazyan, Kenneth J. Breslauer

Research output: Contribution to journalReview articlepeer-review

245 Scopus citations


We review the results of compressibility studies on proteins, nucleic acids, and systematically altered low molecular weight compounds that model the constituents of these biopolymers. The model compound data allow one to define the compressibility properties of water surrounding charged, polar, and nonpolar groups. These results, in conjunction with compressibility data on proteins and nucleic acids, were used to define the properties of water that is perturbed by the presence of these biopolymers in aqueous solutions. Throughout this review, we emphasize the importance of compressibility data for characterizing the hydration properties of solutes (particularly, proteins, nucleic acids, and their constituents), while describing how such data can be interpreted to gain insight into role that hydration can play in modulating the stability of and recognition between biologically important compounds.

Original languageEnglish (US)
Pages (from-to)89-109
Number of pages21
JournalBiophysical chemistry
Issue number2-3
StatePublished - Aug 1994

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry


  • Charged, polar, and nonpolar atomic groups
  • DNA duplexes
  • Globular proteins
  • Hydration
  • Partial compressibility


Dive into the research topics of 'Hydration and partial compressibility of biological compounds'. Together they form a unique fingerprint.

Cite this