Hydration of the phosphate group in double-helical DNA

Bohdan Schneider, Ketan Patel, Helen M. Berman

Research output: Contribution to journalArticlepeer-review

182 Scopus citations


Water distributions around phosphate groups in 59 B-, A-, and Z-DNA crystal structures were analyzed. It is shown that the waters are concentrated in six hydration sites per phosphate and that the positions and occupancies of these sites are dependent on the conformation and type of nucleotide. The patterns of hydration that are characteristic of the backbone of the three DNA helical types can be attributed in part to the interactions of these hydration sites.

Original languageEnglish (US)
Pages (from-to)2422-2434
Number of pages13
JournalBiophysical Journal
Issue number5
StatePublished - Nov 1998

All Science Journal Classification (ASJC) codes

  • Biophysics


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