Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres

Larisa Sheihet, Robert A. Dubin, David Devore, Joachim Kohn

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We describe the synthesis and characterization of a family of biocompatible ABA-triblock copolymers that comprised of hydrophilic A-blocks of poly(ethylene glycol) and hydrophobic B-blocks of oligomers of suberic acid and desaminotyrosyl-tyrosine esters. The triblock copolymers spontaneously self-assemble in aqueous solution into nanospheres, with hydrodynamic diameters between 40 and 70 nm, that do not dissociate under chromatographic and ultracentrifugation conditions. These nanospheres form strong complexes with hydrophobic molecules, including the fluorescent dye 5-dodecanoylaminofluorescein (DAF) and the antitumor drug, paclitaxel, but not with hydrophilic molecules such as fluorescein and Oregon Green. The nanosphere-paclitaxel complexes retain in vitro the high antiproliferative activity of paclitaxel, demonstrating that these nanospheres may be useful for delivery of the hydrophobic drugs.

Original languageEnglish (US)
Pages (from-to)2726-2731
Number of pages6
JournalBiomacromolecules
Volume6
Issue number5
DOIs
StatePublished - Sep 1 2005

Fingerprint

Nanospheres
Drug delivery
Block copolymers
Paclitaxel
Pharmaceutical Preparations
Molecules
Ethylene Glycol
Ultracentrifugation
Hydrodynamics
Fluorescein
Fluorescent Dyes
Oligomers
Antineoplastic Agents
Polyethylene glycols
Tyrosine
Esters
Dyes
Acids

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Sheihet, Larisa ; Dubin, Robert A. ; Devore, David ; Kohn, Joachim. / Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres. In: Biomacromolecules. 2005 ; Vol. 6, No. 5. pp. 2726-2731.
@article{1bc12dd65ff04eeb9e6b2a281d7c23a0,
title = "Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres",
abstract = "We describe the synthesis and characterization of a family of biocompatible ABA-triblock copolymers that comprised of hydrophilic A-blocks of poly(ethylene glycol) and hydrophobic B-blocks of oligomers of suberic acid and desaminotyrosyl-tyrosine esters. The triblock copolymers spontaneously self-assemble in aqueous solution into nanospheres, with hydrodynamic diameters between 40 and 70 nm, that do not dissociate under chromatographic and ultracentrifugation conditions. These nanospheres form strong complexes with hydrophobic molecules, including the fluorescent dye 5-dodecanoylaminofluorescein (DAF) and the antitumor drug, paclitaxel, but not with hydrophilic molecules such as fluorescein and Oregon Green. The nanosphere-paclitaxel complexes retain in vitro the high antiproliferative activity of paclitaxel, demonstrating that these nanospheres may be useful for delivery of the hydrophobic drugs.",
author = "Larisa Sheihet and Dubin, {Robert A.} and David Devore and Joachim Kohn",
year = "2005",
month = "9",
day = "1",
doi = "10.1021/bm050212u",
language = "English (US)",
volume = "6",
pages = "2726--2731",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",
number = "5",

}

Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres. / Sheihet, Larisa; Dubin, Robert A.; Devore, David; Kohn, Joachim.

In: Biomacromolecules, Vol. 6, No. 5, 01.09.2005, p. 2726-2731.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres

AU - Sheihet, Larisa

AU - Dubin, Robert A.

AU - Devore, David

AU - Kohn, Joachim

PY - 2005/9/1

Y1 - 2005/9/1

N2 - We describe the synthesis and characterization of a family of biocompatible ABA-triblock copolymers that comprised of hydrophilic A-blocks of poly(ethylene glycol) and hydrophobic B-blocks of oligomers of suberic acid and desaminotyrosyl-tyrosine esters. The triblock copolymers spontaneously self-assemble in aqueous solution into nanospheres, with hydrodynamic diameters between 40 and 70 nm, that do not dissociate under chromatographic and ultracentrifugation conditions. These nanospheres form strong complexes with hydrophobic molecules, including the fluorescent dye 5-dodecanoylaminofluorescein (DAF) and the antitumor drug, paclitaxel, but not with hydrophilic molecules such as fluorescein and Oregon Green. The nanosphere-paclitaxel complexes retain in vitro the high antiproliferative activity of paclitaxel, demonstrating that these nanospheres may be useful for delivery of the hydrophobic drugs.

AB - We describe the synthesis and characterization of a family of biocompatible ABA-triblock copolymers that comprised of hydrophilic A-blocks of poly(ethylene glycol) and hydrophobic B-blocks of oligomers of suberic acid and desaminotyrosyl-tyrosine esters. The triblock copolymers spontaneously self-assemble in aqueous solution into nanospheres, with hydrodynamic diameters between 40 and 70 nm, that do not dissociate under chromatographic and ultracentrifugation conditions. These nanospheres form strong complexes with hydrophobic molecules, including the fluorescent dye 5-dodecanoylaminofluorescein (DAF) and the antitumor drug, paclitaxel, but not with hydrophilic molecules such as fluorescein and Oregon Green. The nanosphere-paclitaxel complexes retain in vitro the high antiproliferative activity of paclitaxel, demonstrating that these nanospheres may be useful for delivery of the hydrophobic drugs.

UR - http://www.scopus.com/inward/record.url?scp=25844485419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25844485419&partnerID=8YFLogxK

U2 - 10.1021/bm050212u

DO - 10.1021/bm050212u

M3 - Article

C2 - 16153112

AN - SCOPUS:25844485419

VL - 6

SP - 2726

EP - 2731

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

IS - 5

ER -