Hydrothermal approach to a carbon graphite encapsulated FeCo nanocrystals for diagnosis, hyperthermia therapy and siRNA delivery

Joung Kyu Park, Jongjin Jung, Prasad Subramaniam, Birju Shah, Cheoljin Kim, Jong Kyo Lee, Ki Bum Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The carbon graphite encapsulation of metal alloy magnetic nanoparticles has been attracted attention for biological application due to their high magnatization. However, most of the synthetic methods have limitations in terms of scalability and economics owing to the demand synthetic conditions and low yields. Here, we show that well controlled carbon graphite encapsulated FeCo core-shell nanoparticles can be synthesized by hydrothermal method simply mixing iron-cobalt and sucrose as a source of carbon. Various metal ratios between iron and cobalt were produced to determine the compositional dependence of the saturation magnetization and relaxivity coefficient. In addition, we demonstrated that the application for the magnetic resonance imaging (MRI) contrast both in vitro and in vivo and the combination of FeCo/C magnetic nanoparticles-based siRNA delivery against the oncogenic receptor (EGFRvIII) with hyperthermia using the same magnetic nanoparticles results in a synergistic inhibition of brain-tumor cell proliferation and induction of apoptosis.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages367-370
Number of pages4
StatePublished - 2011
EventNanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: Jun 13 2011Jun 16 2011

Publication series

NameTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume1

Other

OtherNanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Country/TerritoryUnited States
CityBoston, MA
Period6/13/116/16/11

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Keywords

  • Hyperthermia
  • Magnetic nanoparticles
  • Magnetic resonance imaging

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