Abstract

Available studies, while limited in number, suggest that e-cigarette vaping induces oxidative stress, with one potential mechanism being the direct formation of reactive oxygen species (ROS) in e-vapor. In the present studies, we measured the formation of hydroxyl radical (·OH), the most destructive ROS, in e-vapor under a range of vaping patterns (i.e., power settings, solvent concentrations, flavorings). Study results show that increased power output and puff volume correspond with the formation of significantly higher amounts of ·OH in e-vapor because of elevated coil temperature and oxygen supply. Vegetable glycerin (VG) e-liquids generated higher ·OH levels than propylene glycol (PG) e-liquids, as did flavored e-liquids relative to nonflavored e-liquids. E-vapor in combination with ascorbic acid, which is an abundant biological molecule in human epithelial lining fluid, can also induce ·OH formation. The dose of radical per puff associated with e-cigarette vaping was 10-1000 times lower than the reported dose generated by cigarette smoking. However, the daily average ·OH dose can be comparable to that from cigarette smoking depending on vaping patterns. Overall, e-cigarette users who use VG-based flavored e-cigarettes at higher power output settings may be at increased risk for ·OH exposures and related health consequences such as asthma and chronic obstructive pulmonary disease.

Original languageEnglish (US)
Pages (from-to)1087-1095
Number of pages9
JournalChemical Research in Toxicology
Volume32
Issue number6
DOIs
StatePublished - Jun 17 2019

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Tobacco Products
Hydroxyl Radical
Vapors
Vegetables
Glycerol
Reactive Oxygen Species
Smoking
Liquids
Propylene Glycol
Chronic Obstructive Pulmonary Disease
Ascorbic Acid
Oxygen supply
Pulmonary diseases
Oxidative Stress
Oxidative stress
Asthma
Oxygen
Linings
Temperature
Vaping

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

@article{5e2e6e3c4986491c9d37ec0743c7eee1,
title = "Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns",
abstract = "Available studies, while limited in number, suggest that e-cigarette vaping induces oxidative stress, with one potential mechanism being the direct formation of reactive oxygen species (ROS) in e-vapor. In the present studies, we measured the formation of hydroxyl radical (·OH), the most destructive ROS, in e-vapor under a range of vaping patterns (i.e., power settings, solvent concentrations, flavorings). Study results show that increased power output and puff volume correspond with the formation of significantly higher amounts of ·OH in e-vapor because of elevated coil temperature and oxygen supply. Vegetable glycerin (VG) e-liquids generated higher ·OH levels than propylene glycol (PG) e-liquids, as did flavored e-liquids relative to nonflavored e-liquids. E-vapor in combination with ascorbic acid, which is an abundant biological molecule in human epithelial lining fluid, can also induce ·OH formation. The dose of radical per puff associated with e-cigarette vaping was 10-1000 times lower than the reported dose generated by cigarette smoking. However, the daily average ·OH dose can be comparable to that from cigarette smoking depending on vaping patterns. Overall, e-cigarette users who use VG-based flavored e-cigarettes at higher power output settings may be at increased risk for ·OH exposures and related health consequences such as asthma and chronic obstructive pulmonary disease.",
author = "Yeongkwon Son and Vladimir Mishin and Laskin, {Jeffrey D.} and Gediminas Mainelis and Wackowski, {Olivia A.} and Cristine Delnevo and Stephan Schwander and Andrey Khlystov and Vera Samburova and Qingyu Meng",
year = "2019",
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language = "English (US)",
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Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns. / Son, Yeongkwon; Mishin, Vladimir; Laskin, Jeffrey D.; Mainelis, Gediminas; Wackowski, Olivia A.; Delnevo, Cristine; Schwander, Stephan; Khlystov, Andrey; Samburova, Vera; Meng, Qingyu.

In: Chemical Research in Toxicology, Vol. 32, No. 6, 17.06.2019, p. 1087-1095.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns

AU - Son, Yeongkwon

AU - Mishin, Vladimir

AU - Laskin, Jeffrey D.

AU - Mainelis, Gediminas

AU - Wackowski, Olivia A.

AU - Delnevo, Cristine

AU - Schwander, Stephan

AU - Khlystov, Andrey

AU - Samburova, Vera

AU - Meng, Qingyu

PY - 2019/6/17

Y1 - 2019/6/17

N2 - Available studies, while limited in number, suggest that e-cigarette vaping induces oxidative stress, with one potential mechanism being the direct formation of reactive oxygen species (ROS) in e-vapor. In the present studies, we measured the formation of hydroxyl radical (·OH), the most destructive ROS, in e-vapor under a range of vaping patterns (i.e., power settings, solvent concentrations, flavorings). Study results show that increased power output and puff volume correspond with the formation of significantly higher amounts of ·OH in e-vapor because of elevated coil temperature and oxygen supply. Vegetable glycerin (VG) e-liquids generated higher ·OH levels than propylene glycol (PG) e-liquids, as did flavored e-liquids relative to nonflavored e-liquids. E-vapor in combination with ascorbic acid, which is an abundant biological molecule in human epithelial lining fluid, can also induce ·OH formation. The dose of radical per puff associated with e-cigarette vaping was 10-1000 times lower than the reported dose generated by cigarette smoking. However, the daily average ·OH dose can be comparable to that from cigarette smoking depending on vaping patterns. Overall, e-cigarette users who use VG-based flavored e-cigarettes at higher power output settings may be at increased risk for ·OH exposures and related health consequences such as asthma and chronic obstructive pulmonary disease.

AB - Available studies, while limited in number, suggest that e-cigarette vaping induces oxidative stress, with one potential mechanism being the direct formation of reactive oxygen species (ROS) in e-vapor. In the present studies, we measured the formation of hydroxyl radical (·OH), the most destructive ROS, in e-vapor under a range of vaping patterns (i.e., power settings, solvent concentrations, flavorings). Study results show that increased power output and puff volume correspond with the formation of significantly higher amounts of ·OH in e-vapor because of elevated coil temperature and oxygen supply. Vegetable glycerin (VG) e-liquids generated higher ·OH levels than propylene glycol (PG) e-liquids, as did flavored e-liquids relative to nonflavored e-liquids. E-vapor in combination with ascorbic acid, which is an abundant biological molecule in human epithelial lining fluid, can also induce ·OH formation. The dose of radical per puff associated with e-cigarette vaping was 10-1000 times lower than the reported dose generated by cigarette smoking. However, the daily average ·OH dose can be comparable to that from cigarette smoking depending on vaping patterns. Overall, e-cigarette users who use VG-based flavored e-cigarettes at higher power output settings may be at increased risk for ·OH exposures and related health consequences such as asthma and chronic obstructive pulmonary disease.

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AN - SCOPUS:85067393064

VL - 32

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JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

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