TY - JOUR
T1 - Hypercoagulability in Arterial Disease
AU - Spillert, Charles R.
AU - Milazzo, Vincent J.
AU - Suval, William D.
AU - Lazaro, Eric J.
PY - 1989/10
Y1 - 1989/10
N2 - Isolated human monocytes generate tissue factor when stimulated with endo toxin. Tissue factor generation provides a marker for activation of the monocyte and of the clotting system. Determination of the recalcification time of blood after incubation with endotoxin detects minute changes in coagulability. This clotting assay was utilized to assess the presence of a hypercoagulable state in patients with peripheral arterial occlusive disease when compared with healthy volunteers. Citrated blood was incubated with endotoxin for two hours, CaCl2 was added, and the recalcification time determined. Hypercoagulability was indicated by shortened recalcification time. The recalcification time ± standard deviation for saline (control) and endotoxin-activated samples from 19 healthy volunteers was 6.55 ±0.8 and 5.69±0.7 minutes, respectively, whereas it was 4.93±1.2 and 4.55 ±0.9 minutes for 31 patients with peripheral arterial occlu sive disease (p <.001 for each). This hypercoagulable state can accentuate the arterial occlusive process in patients with peripheral vascular disease and may prove to be of diagnostic, therapeutic, and prognostic significance.
AB - Isolated human monocytes generate tissue factor when stimulated with endo toxin. Tissue factor generation provides a marker for activation of the monocyte and of the clotting system. Determination of the recalcification time of blood after incubation with endotoxin detects minute changes in coagulability. This clotting assay was utilized to assess the presence of a hypercoagulable state in patients with peripheral arterial occlusive disease when compared with healthy volunteers. Citrated blood was incubated with endotoxin for two hours, CaCl2 was added, and the recalcification time determined. Hypercoagulability was indicated by shortened recalcification time. The recalcification time ± standard deviation for saline (control) and endotoxin-activated samples from 19 healthy volunteers was 6.55 ±0.8 and 5.69±0.7 minutes, respectively, whereas it was 4.93±1.2 and 4.55 ±0.9 minutes for 31 patients with peripheral arterial occlu sive disease (p <.001 for each). This hypercoagulable state can accentuate the arterial occlusive process in patients with peripheral vascular disease and may prove to be of diagnostic, therapeutic, and prognostic significance.
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U2 - 10.1177/000331978904001005
DO - 10.1177/000331978904001005
M3 - Article
C2 - 2802258
AN - SCOPUS:0024450716
VL - 40
SP - 886
EP - 889
JO - Angiology
JF - Angiology
SN - 0003-3197
IS - 10
ER -