Hyperthermia in a differentiating murine erythroleukemia cell line: Cell killing by heat and radiation

G. P. Raaphorst, E. I. Azzam, J. Borsa, M. Einspenner

Research output: Contribution to journalArticlepeer-review


The survival response of Friend erythroleukemia cells (a differentiating cell system) to heat and radiation has been examined. The Friend erythroleukemia cells (FELC) were more heat and radiation sensitive than V79 cells, and the heat and radiation survival curves possessed shoulders, showing the ability of the cells to accumulate sublethal damage. Thermal tolerance was expressed after prolonged heating at 41·0-42·0°C. Thermal radiosensitization by heating at 42·0 or 45·0°C was greatest for simultaneous heat and radiation treatments, and recovery occurred when the cells were incubated at 37°C between the heat and radiation or radiation and heat treatments. Arrhenius analysis of the FELC heat survival data showed that the curve for thermal inactivation possessed a break at about 43·0°C and that the thermal inactivation energies above and below the break point were comparable to those for V79 cells and other cell lines reported in the literature.

Original languageEnglish (US)
Pages (from-to)275-283
Number of pages9
JournalInternational Journal of Radiation Biology
Issue number3
StatePublished - 1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


  • Cell killing
  • Friend erythroleukemia cells
  • Hyperthermia
  • X-rays


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