TY - JOUR
T1 - Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
AU - Tang, Wenping
AU - Zhan, Jianfeng
AU - Li, Shiming
AU - Liu, Yue
AU - Ho, Chi Tang
N1 - Funding Information:
This work was supported by Hubei Science and Technology Plan key Project, Hubei Province, China (2019ABA100).
Funding Information:
This work was supported by Hubei Science and Technology Plan key Project, Hubei Province , China ( 2019ABA100 ).
Publisher Copyright:
© 2022
PY - 2022/9
Y1 - 2022/9
N2 - In 2021, there are approximately 537 million adults ageing 20[sbnd]79 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating diseases such as diabetes. Both as a food and an herbal medicine, Polygonum multiflorum (PM) has been used as an anti-aging tonic, for hair darkening in traditional Chinese medicine for several centuries. The recent research effort of PM has been focused on antioxidant, anti-ageing and anti-tumor properties. In the present study, we utilized the traditional processing of harvested raw PM, and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract (PME). PME (0.075 %) was given to diabetic mice (KK CgAy/J) in drinking water and after 7 weeks, PME-treated mice had significantly lower glucose levels than mice in the diabetic control group (P < 0.01). The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintaining β-cell function.
AB - In 2021, there are approximately 537 million adults ageing 20[sbnd]79 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating diseases such as diabetes. Both as a food and an herbal medicine, Polygonum multiflorum (PM) has been used as an anti-aging tonic, for hair darkening in traditional Chinese medicine for several centuries. The recent research effort of PM has been focused on antioxidant, anti-ageing and anti-tumor properties. In the present study, we utilized the traditional processing of harvested raw PM, and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract (PME). PME (0.075 %) was given to diabetic mice (KK CgAy/J) in drinking water and after 7 weeks, PME-treated mice had significantly lower glucose levels than mice in the diabetic control group (P < 0.01). The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintaining β-cell function.
KW - Diabetes
KW - Homeostatic model assessment
KW - Hypoglycemic activity
KW - Polygonum multiflorum
KW - Stilbene glycoside
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U2 - 10.1016/j.fshw.2022.04.013
DO - 10.1016/j.fshw.2022.04.013
M3 - Article
AN - SCOPUS:85132413242
SN - 2213-4530
VL - 11
SP - 1177
EP - 1182
JO - Food Science and Human Wellness
JF - Food Science and Human Wellness
IS - 5
ER -